| Literature DB >> 29310006 |
Łukasz Lewandowski1, Marta Kepinska2, Halina Milnerowicz1.
Abstract
The function of Cu,Zn-SOD is to dismutate superoxide into hydrogen peroxide and oxygen. This task is fulfilled due to structural nuances of the enzyme. Many environmental xenobiotics have been proved to inhibit Cu,Zn-SOD. Those compounds could be found not only in industrial sewage, cigarettes and various chemical agents - some of them are used as drugs, drug production substrates or are the product of drug biotransformation. Cu,Zn-SOD exposition to these compounds leads to inhibition due to: copper ion chelation, unfolding the structure of the enzyme, affecting residues vital for activity maintenance. This review covers a selection of Cu,Zn-SOD inhibitors, referring to in vivo and in vitro study.Entities:
Keywords: Copper-zinc superoxide dismutase; Enzyme activity; Inhibition
Mesh：
Substances：
Year: 2017 PMID： 29310006 DOI： 10.1016/j.etap.2017.12.022
Source DB: PubMed Journal: Environ Toxicol Pharmacol ISSN： 1382-6689 Impact factor: 4.860