| Literature DB >> 29307501 |
Laura E Kwako1, Warren K Bickel2, David Goldman3.
Abstract
Trends towards dimensional approaches in understanding psychiatric disorders may also be applied to addictive disorders. Advances in our understanding of the neurobiology of addiction can inform these efforts. Furthermore, dimensional approaches to addiction, such as the proposed Addictions Neuroclinical Assessment (ANA), may be used in identifying novel addiction biomarkers, and refining ones that currently exist. These biomarkers, derived from both an understanding of the neurobiology of addiction and behavioral phenotypes, represent a departure from traditional markers of alcohol-relevant biomarkers, such as tests of liver function (LFTs). We posit that a potential addiction-relevant biomarker is reinforcer pathology, found to be relevant across addictions to different substances, and which may offer a target for modification through the use of episodic future thinking.Entities:
Keywords: addiction; biomarkers; nosology
Mesh:
Substances:
Year: 2018 PMID: 29307501 PMCID: PMC6233300 DOI: 10.1016/j.molmed.2017.12.007
Source DB: PubMed Journal: Trends Mol Med ISSN: 1471-4914 Impact factor: 11.951