Literature DB >> 29306970

Preoperative decolonization to reduce infections in urgent lower extremity repairs.

Daniel S Urias1, Merin Varghese2,3, Thomas Simunich2, Shawna Morrissey2, Russell Dumire2.   

Abstract

PURPOSE: Medical implants and surgical site infections (SSIs) can be a burden on both patients and healthcare systems with a significant rise in morbidity, mortality and costs. Preoperatively, our practice of a chlorohexidine gluconate (CHG) washcloth bath or solution shower was supplemented with nasal painting using povidone-iodine skin and nasal antiseptic (PI-SNA). We sought to measure the effectiveness in reducing SSIs in patients undergoing repair of lower extremity fractures.
METHODS: A retrospective review of trauma patients undergoing orthopedic operations conducted at Conemaugh Memorial Medical Center from 10/1/2012 through 9/30/2016. The intervention period was 10/1/2014 to 9/30/2016 which included the addition of nasal painting with PI-SNA preoperatively. All patients were followed for 1 year prior to January 2013 and 30 or 90 days thereafter for the development of a SSI.
RESULTS: The pre-intervention group consisted of 930 cases with a 1.1% infection rate (10 SSIs). The intervention group consisted of 962 cases with a 0.2% infection rate (2 SSIs). This observed difference was statistically significant (P = 0.020).
CONCLUSIONS: This retrospective review of a methicillin-resistant Staphylococcus aureus decolonization protocol using CHG bath/shower and PI-SNA nasal painting revealed a significant decrease in the infection rate of patients undergoing lower extremity fracture repairs. We recommend its use without contraindications, but recognize that additional investigations are necessary.

Entities:  

Keywords:  Decolonization; Fractures; MRSA; Povidone-iodine; Surgical site infection; Trauma

Mesh:

Substances:

Year:  2018        PMID: 29306970     DOI: 10.1007/s00068-017-0896-1

Source DB:  PubMed          Journal:  Eur J Trauma Emerg Surg        ISSN: 1863-9933            Impact factor:   3.693


  16 in total

1.  Guideline for prevention of surgical site infection, 1999. Hospital Infection Control Practices Advisory Committee.

Authors:  A J Mangram; T C Horan; M L Pearson; L C Silver; W R Jarvis
Journal:  Infect Control Hosp Epidemiol       Date:  1999-04       Impact factor: 3.254

Review 2.  Estimating the proportion of healthcare-associated infections that are reasonably preventable and the related mortality and costs.

Authors:  Craig A Umscheid; Matthew D Mitchell; Jalpa A Doshi; Rajender Agarwal; Kendal Williams; Patrick J Brennan
Journal:  Infect Control Hosp Epidemiol       Date:  2011-02       Impact factor: 3.254

3.  Efficacy of skin and nasal povidone-iodine preparation against mupirocin-resistant methicillin-resistant Staphylococcus aureus and S. aureus within the anterior nares.

Authors:  Michele J Anderson; Maren L David; Matt Scholz; Sally J Bull; Dan Morse; Michelle Hulse-Stevens; Marnie L Peterson
Journal:  Antimicrob Agents Chemother       Date:  2015-03-02       Impact factor: 5.191

4.  Intranasal mupirocin reduces sternal wound infection after open heart surgery in diabetics and nondiabetics.

Authors:  G E Cimochowski; M D Harostock; R Brown; M Bernardi; N Alonzo; K Coyle
Journal:  Ann Thorac Surg       Date:  2001-05       Impact factor: 4.330

5.  Prophylactic mupirocin could reduce orthopedic wound infections. 1,044 patients treated with mupirocin compared with 1,260 historical controls.

Authors:  A J Gernaat-van der Sluis; A M Hoogenboom-Verdegaal; P J Edixhoven; N H Spies-van Rooijen
Journal:  Acta Orthop Scand       Date:  1998-08

6.  Preventing surgical-site infections in nasal carriers of Staphylococcus aureus.

Authors:  Lonneke G M Bode; Jan A J W Kluytmans; Heiman F L Wertheim; Diana Bogaers; Christina M J E Vandenbroucke-Grauls; Robert Roosendaal; Annet Troelstra; Adrienne T A Box; Andreas Voss; Ingeborg van der Tweel; Alex van Belkum; Henri A Verbrugh; Margreet C Vos
Journal:  N Engl J Med       Date:  2010-01-07       Impact factor: 91.245

7.  Preventing surgical site infections: a randomized, open-label trial of nasal mupirocin ointment and nasal povidone-iodine solution.

Authors:  Michael Phillips; Andrew Rosenberg; Bo Shopsin; Germaine Cuff; Faith Skeete; Alycia Foti; Kandy Kraemer; Kenneth Inglima; Robert Press; Joseph Bosco
Journal:  Infect Control Hosp Epidemiol       Date:  2014-05-21       Impact factor: 3.254

8.  Povidone-Iodine-Based Solutions for Decolonization of Nasal Staphylococcus aureus: A Randomized, Prospective, Placebo-Controlled Study.

Authors:  Maryam Rezapoor; Thema Nicholson; Reza Mostafavi Tabatabaee; Antonia F Chen; Mitchell G Maltenfort; Javad Parvizi
Journal:  J Arthroplasty       Date:  2017-05-03       Impact factor: 4.757

9.  Severe surgical site infection in community hospitals: epidemiology, key procedures, and the changing prevalence of methicillin-resistant Staphylococcus aureus.

Authors:  Deverick J Anderson; Daniel J Sexton; Zeina A Kanafani; Grace Auten; Keith S Kaye
Journal:  Infect Control Hosp Epidemiol       Date:  2007-07-12       Impact factor: 3.254

10.  Multistate point-prevalence survey of health care-associated infections.

Authors:  Shelley S Magill; Jonathan R Edwards; Wendy Bamberg; Zintars G Beldavs; Ghinwa Dumyati; Marion A Kainer; Ruth Lynfield; Meghan Maloney; Laura McAllister-Hollod; Joelle Nadle; Susan M Ray; Deborah L Thompson; Lucy E Wilson; Scott K Fridkin
Journal:  N Engl J Med       Date:  2014-03-27       Impact factor: 91.245

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  3 in total

Review 1.  Povidone Iodine: Properties, Mechanisms of Action, and Role in Infection Control and Staphylococcus aureus Decolonization.

Authors:  Didier Lepelletier; Jean Yves Maillard; Bruno Pozzetto; Anne Simon
Journal:  Antimicrob Agents Chemother       Date:  2020-08-20       Impact factor: 5.191

Review 2.  Preoperative Intranasal Decolonization with Topical Povidone-Iodine Antiseptic and the Incidence of Surgical Site Infection: A Review.

Authors:  Vidmi Taolam Martin; Mohamed Abdullahi Abdi; Jie Li; Dongtai Li; Zhaozhen Wang; Xianliao Zhang; Welera Haissou Elodie; Bo Yu
Journal:  Med Sci Monit       Date:  2020-12-11

3.  Nasal povidone-iodine implementation for preventing surgical site infections: Perspectives of surgical nurses.

Authors:  Eric N Hammond; Nicole Brys; Ashley Kates; Jackson S Musuuza; Ambar Haleem; Michael L Bentz; Nasia Safdar
Journal:  PLoS One       Date:  2020-11-19       Impact factor: 3.240

  3 in total

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