Neal Bhutiani1, Charles R Scoggins1, Kelly M McMasters1, Cecilia G Ethun2, George A Poultsides3, Timothy M Pawlik4, Sharon M Weber5, Carl R Schmidt4, Ryan C Fields6, Kamran Idrees7, Ioannis Hatzaras8, Perry Shen9, Shishir K Maithel2, Robert C G Martin10. 1. Department of Surgery, University of Louisville, Louisville, KY. 2. Department of Surgery, Emory University, Atlanta, GA. 3. Department of Surgery, Stanford University, Palo Alto, CA. 4. Department of Surgery, The Ohio State University, Columbus, OH. 5. Department of Surgery, University of Wisconsin, Madison, WI. 6. Department of Surgery, Washington University, St. Louis, MO. 7. Department of Surgery, Vanderbilt University, Nashville, TN. 8. Department of Surgery, New York University, New York, NY. 9. Department of Surgery, Wake Forest University, Winston-Salem, NC. 10. Department of Surgery, University of Louisville, Louisville, KY. Electronic address: robert.martin@louisville.edu.
Abstract
BACKGROUND: The objective of this study was to determine the impact of caudate resection on margin status and outcomes during resection of extrahepatic hilar cholangiocarcinoma. METHODS: A database of 1,092 patients treated for biliary malignancies at institutions of the Extrahepatic Biliary Malignancy Consortium was queried for individuals undergoing curative-intent resection for extrahepatic hilar cholangiocarcinoma. Patients who did versus did not undergo concomitant caudate resection were compared with regard to demographic, baseline, and tumor characteristics as well as perioperative outcomes. RESULTS: A total of 241 patients underwent resection for a hilar cholangiocarcinoma, of whom 85 underwent caudate resection. Patients undergoing caudate resection were less likely to have a final positive margin (P = .01). Kaplan-Meier curve of overall survival for patients undergoing caudate resection indicated no improvement over patients not undergoing caudate resection (P = .16). On multivariable analysis, caudate resection was not associated with improved overall survival or recurrence-free survival, although lymph node positivity was associated with worse overall survival and recurrence-free survival, and adjuvant chemoradiotherapy was associated with improved overall survival and recurrence-free survival. CONCLUSION: Caudate resection is associated with a greater likelihood of margin-negative resection in patients with extrahepatic hilar cholangiocarcinoma. Precise preoperative imaging is critical to assess the extent of biliary involvement, so that all degrees of hepatic resections are possible at the time of the initial operation.
BACKGROUND: The objective of this study was to determine the impact of caudate resection on margin status and outcomes during resection of extrahepatic hilar cholangiocarcinoma. METHODS: A database of 1,092 patients treated for biliary malignancies at institutions of the Extrahepatic Biliary Malignancy Consortium was queried for individuals undergoing curative-intent resection for extrahepatic hilar cholangiocarcinoma. Patients who did versus did not undergo concomitant caudate resection were compared with regard to demographic, baseline, and tumor characteristics as well as perioperative outcomes. RESULTS: A total of 241 patients underwent resection for a hilar cholangiocarcinoma, of whom 85 underwent caudate resection. Patients undergoing caudate resection were less likely to have a final positive margin (P = .01). Kaplan-Meier curve of overall survival for patients undergoing caudate resection indicated no improvement over patients not undergoing caudate resection (P = .16). On multivariable analysis, caudate resection was not associated with improved overall survival or recurrence-free survival, although lymph node positivity was associated with worse overall survival and recurrence-free survival, and adjuvant chemoradiotherapy was associated with improved overall survival and recurrence-free survival. CONCLUSION: Caudate resection is associated with a greater likelihood of margin-negative resection in patients with extrahepatic hilar cholangiocarcinoma. Precise preoperative imaging is critical to assess the extent of biliary involvement, so that all degrees of hepatic resections are possible at the time of the initial operation.
Authors: Richard W D Gilbert; Tori Lenet; Sean P Cleary; Rory Smoot; Ching-Wei D Tzeng; Flavio G Rocha; Guillaume Martel; Kimberly A Bertens Journal: Ann Surg Oncol Date: 2022-06-15 Impact factor: 4.339