Literature DB >> 2930496

Adipsin mRNA amounts are not decreased in the genetically obese Zucker rat.

I Dugail1, X Le Liepvre, A Quignard-Boulangé, J Pairault, M Lavau.   

Abstract

Adipsin gene expression as assessed by mRNA amounts was examined in adipose tissue of genetically obese rats at the onset (16 days of age) or at later stages (30 and 60 days of age) of obesity. Amounts of mRNA were equivalent in obese and lean rats at 16 days of age. In adult rats, we observed a 2-fold decrease in adipsin mRNA in the obese rats compared with control lean rats, which was abolished by weaning the animals on a high-fat diet. Our data show that, in sharp contrast with genetically obese mice, adipsin mRNA is not suppressed in genetically obese Zucker rats.

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Year:  1989        PMID： 2930496      PMCID： PMC1135675          DOI： 10.1042/bj2570917

Source DB:  PubMed          Journal:  Biochem J        ISSN： 0264-6021            Impact factor:   3.857


  16 in total

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Authors:  G A Bray; D A York
Journal:  Physiol Rev       Date:  1979-07       Impact factor: 37.312

2.  A developmentally regulated mRNA from 3T3 adipocytes encodes a novel serine protease homologue.

Authors:  K S Cook; D L Groves; H Y Min; B M Spiegelman
Journal:  Proc Natl Acad Sci U S A       Date:  1985-10       Impact factor: 11.205

3.  Basal corticosterone levels of young og/ob mice.

Authors:  P U Dubuc
Journal:  Horm Metab Res       Date:  1977-01       Impact factor: 2.936

4.  Effect of corticotropin on brown adipose tissue mitochondrial GDP binding in obese rats.

Authors:  D A York; I Al-Baker
Journal:  Biochem J       Date:  1984-10-01       Impact factor: 3.857

5.  A method for isolation of intact, translationally active ribonucleic acid.

Authors:  G Cathala; J F Savouret; B Mendez; B L West; M Karin; J A Martial; J D Baxter
Journal:  DNA       Date:  1983

6.  Molecular cloning of mRNA from 3T3 adipocytes. Regulation of mRNA content for glycerophosphate dehydrogenase and other differentiation-dependent proteins during adipocyte development.

Authors:  B M Spiegelman; M Frank; H Green
Journal:  J Biol Chem       Date:  1983-08-25       Impact factor: 5.157

7.  Inguinal fat pad weight plotted versus body weight as a method of genotype identification in 16-day-old Zucker rats.

Authors:  M Lavau; R Bazin
Journal:  J Lipid Res       Date:  1982-08       Impact factor: 5.922

8.  Diurnal rhythm for corticosterone in obese (ob/ob) diabetes (db/db) and gold-thioglucose-induced obesity in mice.

Authors:  M Saito; G A Bray
Journal:  Endocrinology       Date:  1983-12       Impact factor: 4.736

9.  Adipose-tissue-specific increase in glyceraldehyde-3-phosphate dehydrogenase activity and mRNA amounts in suckling pre-obese Zucker rats. Effect of weaning.

Authors:  I Dugail; A Quignard-Boulange; R Bazin; X Le Liepvre; M Lavau
Journal:  Biochem J       Date:  1988-09-01       Impact factor: 3.857

10.  Development of hepatic and adipose tissue lipogenic enzymes and insulinemia during suckling and weaning on to a high-fat diet in Zucker rats.

Authors:  R Bazin; M Lavau
Journal:  J Lipid Res       Date:  1982-08       Impact factor: 5.922
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  2 in total

Review 1.  Regulation of gene expression by insulin.

Authors:  R M O'Brien; D K Granner
Journal:  Biochem J       Date:  1991-09-15       Impact factor: 3.857

2.  Gene expression of lipid storage-related enzymes in adipose tissue of the genetically obese Zucker rat. Co-ordinated increase in transcriptional activity and potentiation by hyperinsulinaemia.

Authors:  I Dugail; A Quignard-Boulangé; X Le Liepvre; B Ardouin; M Lavau
Journal:  Biochem J       Date:  1992-02-01       Impact factor: 3.857
  2 in total

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