Dong Guo1,2, Anqin Han2, Wang Jing2,3, Dawei Chen2, Feng Jin2, Minghuan Li, Li Kong2, Jinming Yu2. 1. Weifang Medical University, Weifang, PR China. 2. Department of Radiotherapy, Shandong Cancer Hospital Affiliated to Shandong University, Jinan, PR China. 3. Department of Radiotherapy, the First Affiliated Hospital to Zhengzhou University, Zhengzhou, PR China.
Abstract
AIM: To evaluate the prognostic value of preoperative to postoperative neutrophil-to-lymphocyte ratio changes (ΔNLR) in patients undergoing surgical resection for colorectal cancer. PATIENTS & METHODS: Data of 135 such patients managed at the Shandong Cancer Hospital and Institute were retrospectively analyzed. Clinicopathologic factors, overall survival (OS) and disease-free survival (DFS) were assessed using Kaplan-Meier curves and Cox regression models. RESULTS: In the multivariate analysis, preoperative NLR (p = 0.002) and ΔNLR (p = 0.037) independently predicted OS, but preoperative NLR (p = 0.141) and ΔNLR (p = 0.297) were not significant prognosticators for DFS. CONCLUSION: Our results demonstrated the prognostic value of the ΔNLR in predicting OS in patients undergoing surgical resection for colorectal cancer. However, ΔNLR could not predict DFS.
AIM: To evaluate the prognostic value of preoperative to postoperative neutrophil-to-lymphocyte ratio changes (ΔNLR) in patients undergoing surgical resection for colorectal cancer. PATIENTS & METHODS: Data of 135 such patients managed at the Shandong Cancer Hospital and Institute were retrospectively analyzed. Clinicopathologic factors, overall survival (OS) and disease-free survival (DFS) were assessed using Kaplan-Meier curves and Cox regression models. RESULTS: In the multivariate analysis, preoperative NLR (p = 0.002) and ΔNLR (p = 0.037) independently predicted OS, but preoperative NLR (p = 0.141) and ΔNLR (p = 0.297) were not significant prognosticators for DFS. CONCLUSION: Our results demonstrated the prognostic value of the ΔNLR in predicting OS in patients undergoing surgical resection for colorectal cancer. However, ΔNLR could not predict DFS.
Authors: H G Jones; E Qasem; N Dilaver; R Egan; O Bodger; R Kokelaar; M D Evans; M Davies; J Beynon; D Harris Journal: Int J Colorectal Dis Date: 2018-04-28 Impact factor: 2.571
Authors: Daniel José Szor; André Roncon Dias; Marina Alessandra Pereira; Marcus Fernando Kodama Pertille Ramos; Bruno Zilberstein; Ivan Cecconello; Ulysses Ribeiro Júnior Journal: Einstein (Sao Paulo) Date: 2019-11-25