Literature DB >> 29299857

Synthesis and structure-activity relationship study of diaryl[d,f][1,3]diazepines as potential anti-cancer agents.

Longjia Yan1, Hui Wang2, Yunpeng Chen2, Zhiwei Li2, Yazhong Pei3.   

Abstract

We herein report the synthesis, biological activity and preliminary structure-activity relationships of a series of diaryl[1,3]diazepines. These compounds were able to inhibit the proliferation of many cancer cell lines, such as HeLa, MCF-7, SGC7901 and A549. When HeLa cells were treated with lead compounds 7j and 7k at 3 [Formula: see text] concentration, cell arrest was observed in the G2/M phase.

Entities:  

Keywords:  Anti-cancer activity; Benzo[13]diazepine; Diaryl[][13]diazepine; Structure–activity relationship

Mesh：

Substances：

Year:  2018        PMID： 29299857     DOI： 10.1007/s11030-017-9805-0

Source DB:  PubMed          Journal:  Mol Divers        ISSN： 1381-1991            Impact factor:   2.943


  22 in total

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2.  Kinase domain mutations in cancer: implications for small molecule drug design strategies.

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Journal:  J Med Chem       Date:  2009-03-26       Impact factor: 7.446

Review 3.  Apoptosis in cancer.

Authors:  S W Lowe; A W Lin
Journal:  Carcinogenesis       Date:  2000-03       Impact factor: 4.944

4.  Cancer screening in the United States, 2011: A review of current American Cancer Society guidelines and issues in cancer screening.

Authors:  Robert A Smith; Vilma Cokkinides; Durado Brooks; Debbie Saslow; Mona Shah; Otis W Brawley
Journal:  CA Cancer J Clin       Date:  2011-01-04       Impact factor: 508.702

Review 5.  Role of tyrosine kinase inhibitors in cancer therapy.

Authors:  Amit Arora; Eric M Scholar
Journal:  J Pharmacol Exp Ther       Date:  2005-07-07       Impact factor: 4.030

Review 6.  Mechanisms of drug resistance in cancer chemotherapy.

Authors:  Y A Luqmani
Journal:  Med Princ Pract       Date:  2005       Impact factor: 1.927

7.  Effects of ecopipam, a selective dopamine D1 antagonist, on smoked cocaine self-administration by humans.

Authors:  M Haney; A S Ward; R W Foltin; M W Fischman
Journal:  Psychopharmacology (Berl)       Date:  2001-06       Impact factor: 4.530

8.  Cortical dopamine D(1) receptors in type 1 and type 2 alcoholics measured with human whole hemisphere autoradiography.

Authors:  Erkki Tupala; Jari Tiihonen
Journal:  Psychiatry Res       Date:  2007-12-11       Impact factor: 3.222

Review 9.  Protein kinase C family: on the crossroads of cell signaling in skin and tumor epithelium.

Authors:  D Breitkreutz; L Braiman-Wiksman; N Daum; M F Denning; T Tennenbaum
Journal:  J Cancer Res Clin Oncol       Date:  2007-07-28       Impact factor: 4.553

Review 10.  Involvement of signal transduction cascade via dopamine-D1 receptors in phencyclidine dependence.

Authors:  Yukihiro Noda; Toshitaka Nabeshima
Journal:  Ann N Y Acad Sci       Date:  2004-10       Impact factor: 5.691
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  3 in total

1.  Microwave-assisted synthesis of 7-azaindoles via iron-catalyzed cyclization of an o-haloaromatic amine with terminal alkynes.

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Journal:  RSC Adv       Date:  2019-12-02       Impact factor: 3.361

2.  Synthesis and preliminary structure-activity relationship study of 3-methylquinazolinone derivatives as EGFR inhibitors with enhanced antiproliferative activities against tumour cells.

Authors:  Yan Zhang; Qin Wang; Luolan Li; Yi Le; Li Liu; Jing Yang; Yongliang Li; Guochen Bao; Longjia Yan
Journal:  J Enzyme Inhib Med Chem       Date:  2021-12       Impact factor: 5.051

3.  Design, synthesis and in vitro biological evaluation of quinazolinone derivatives as EGFR inhibitors for antitumor treatment.

Authors:  Yi Le; Yiyuan Gan; Yihong Fu; Jiamin Liu; Wen Li; Xue Zou; Zhixu Zhou; Zhenchao Wang; Guiping Ouyang; Longjia Yan
Journal:  J Enzyme Inhib Med Chem       Date:  2020-12       Impact factor: 5.051
  3 in total

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