Caroline Tanner1,2, Karen Marder3, Shirley Eberly4, Kevin Biglan5,6, David Oakes4, Ira Shoulson7. 1. Parkinson's Disease Research, Education and Clinical Center, Neurology, San Francisco Veterans Affairs Medical Center, San Francisco, California, USA. 2. Department of Neurology, University of California-San Francisco, San Francisco, California, USA. 3. Departments of Neurology and Psychiatry, Taub Institute for Research on the Aging Brain, Gertrude H. Sergievsky Center, Columbia University College of Physicians and Surgeons, New York, New York, USA. 4. Department of Biostatistics and Computational Biology, University of Rochester, New York, New York, USA. 5. Eli Lilly and Company, Indianapolis, Indiana, USA. 6. Department of Neurology, University of Rochester, New York, New York, USA. 7. Department of Neurology, Georgetown University, Washington, D.C., USA.
Abstract
BACKGROUND: In Huntington's disease, 60% of the variance in onset age is not explained by the huntingtin gene mutation. Huntington's disease onset was earlier in caffeine users. OBJECTIVE: The objective of this study was to assess the relationship of lifestyle factors with motor phenoconversion among persons at risk for Huntington's disease. METHODS: The associations of motor phenoconversion and exposure to selected lifestyle and health factors were examined using Cox proportional hazards analyses adjusted for age, gender, and repeat length. RESULTS: Of 247 participants, 36 (14.6%) phenoconverted. Mean follow-up was 4.2 years. Greater caffeinated soda use was associated with an increased hazard of phenoconversion: moderate use hazard ratio 2.26 (95% confidence interval 0.59-8.71), high use hazard ratio 4.05 (95% confidence interval 1.18-13.96). CONCLUSIONS: Huntington's disease onset was earlier among consumers of caffeinated soda, but not other caffeinated beverages. This finding may be spurious or not related to caffeine.
BACKGROUND: In Huntington's disease, 60% of the variance in onset age is not explained by the huntingtin gene mutation. Huntington's disease onset was earlier in caffeine users. OBJECTIVE: The objective of this study was to assess the relationship of lifestyle factors with motor phenoconversion among persons at risk for Huntington's disease. METHODS: The associations of motor phenoconversion and exposure to selected lifestyle and health factors were examined using Cox proportional hazards analyses adjusted for age, gender, and repeat length. RESULTS: Of 247 participants, 36 (14.6%) phenoconverted. Mean follow-up was 4.2 years. Greater caffeinated soda use was associated with an increased hazard of phenoconversion: moderate use hazard ratio 2.26 (95% confidence interval 0.59-8.71), high use hazard ratio 4.05 (95% confidence interval 1.18-13.96). CONCLUSIONS:Huntington's disease onset was earlier among consumers of caffeinated soda, but not other caffeinated beverages. This finding may be spurious or not related to caffeine.
Authors: G W Ross; R D Abbott; H Petrovitch; D M Morens; A Grandinetti; K H Tung; C M Tanner; K H Masaki; P L Blanchette; J D Curb; J S Popper; L R White Journal: JAMA Date: 2000 May 24-31 Impact factor: 56.272
Authors: Samuel M Goldman; Caroline M Tanner; David Oakes; Grace S Bhudhikanok; Anjali Gupta; J William Langston Journal: Ann Neurol Date: 2006-07 Impact factor: 10.422
Authors: Jose Luis López-Sendón; Ana Royuela; Patricia Trigo; Michael Orth; Herwig Lange; Ralf Reilmann; Jennifer Keylock; Hugh Rickards; Silvia Piacentini; Ferdinando Squitieri; Bernhard Landwehrmeyer; Marie-Noelle Witjes-Ane; Caroline K Jurgens; Raymund A C Roos; Victor Abraira; Justo G de Yébenes Journal: Mov Disord Date: 2011-03-22 Impact factor: 10.338
Authors: Caroline M Tanner; G Webster Ross; Sarah A Jewell; Robert A Hauser; Joseph Jankovic; Stewart A Factor; Susan Bressman; Amanda Deligtisch; Connie Marras; Kelly E Lyons; Grace S Bhudhikanok; Diana F Roucoux; Cheryl Meng; Robert D Abbott; J William Langston Journal: Arch Neurol Date: 2009-09