Robert I Smee1. 1. Department of Radiation Oncology, The Prince of Wales Cancer Centre, High St, Randwick, New South Wales, Australia.
Abstract
PURPOSE: To evaluate the circumstances relating to Radiation Associated Meningiomas (RAM) and whether repeat radiotherapy can be used. MATERIALS AND METHODS: In this Ethics Approved Study, databases of the Long Term Follow-Up Clinic at Sydney Children's Hospital and the Prince of Wales Cancer Centre were audited for patients who received radiotherapy to the head as a child, and subsequently developed an intracranial meningioma. Features noted were, initial diagnosis, extent of prior treatment, dose, latency to diagnosis, subsequent treatment, and outcome. RESULTS: There were 18 patients with an equal gender mix of males/females (9), the majority of patients being treated with whole brain radiotherapy for leukaemia prophylaxis. 6 patients had radiotherapy, 4 had follow-up out to 17 years with no further adverse event, and control of the meningioma. CONCLUSION: Surgery may still be the treatment of choice, however where appropriate radiotherapy can be considered, with good prospect of benefit to the patient.
PURPOSE: To evaluate the circumstances relating to Radiation Associated Meningiomas (RAM) and whether repeat radiotherapy can be used. MATERIALS AND METHODS: In this Ethics Approved Study, databases of the Long Term Follow-Up Clinic at Sydney Children's Hospital and the Prince of Wales Cancer Centre were audited for patients who received radiotherapy to the head as a child, and subsequently developed an intracranial meningioma. Features noted were, initial diagnosis, extent of prior treatment, dose, latency to diagnosis, subsequent treatment, and outcome. RESULTS: There were 18 patients with an equal gender mix of males/females (9), the majority of patients being treated with whole brain radiotherapy for leukaemia prophylaxis. 6 patients had radiotherapy, 4 had follow-up out to 17 years with no further adverse event, and control of the meningioma. CONCLUSION: Surgery may still be the treatment of choice, however where appropriate radiotherapy can be considered, with good prospect of benefit to the patient.
Authors: V King; L S Constine; D Clark; R G Schwartz; A G Muhs; M Henzler; A Hutson; P Rubin Journal: Int J Radiat Oncol Biol Phys Date: 1996-11-01 Impact factor: 7.038
Authors: J Debus; M Wuendrich; A Pirzkall; A Hoess; W Schlegel; I Zuna; R Engenhart-Cabillic; M Wannenmacher Journal: J Clin Oncol Date: 2001-08-01 Impact factor: 44.544
Authors: Thomas J Galloway; Daniel J Indelicato; Robert J Amdur; Erika L Swanson; Christopher G Morris; Robert B Marcus Journal: Int J Radiat Oncol Biol Phys Date: 2010-04-24 Impact factor: 7.038
Authors: Kevin C Oeffinger; Ann C Mertens; Charles A Sklar; Toana Kawashima; Melissa M Hudson; Anna T Meadows; Debra L Friedman; Neyssa Marina; Wendy Hobbie; Nina S Kadan-Lottick; Cindy L Schwartz; Wendy Leisenring; Leslie L Robison Journal: N Engl J Med Date: 2006-10-12 Impact factor: 176.079
Authors: Debra L Friedman; John Whitton; Wendy Leisenring; Ann C Mertens; Sue Hammond; Marilyn Stovall; Sarah S Donaldson; Anna T Meadows; Leslie L Robison; Joseph P Neglia Journal: J Natl Cancer Inst Date: 2010-07-15 Impact factor: 11.816