PURPOSE: To report the outcome of patients treated at the University of Florida who developed meningiomas after radiation to the central nervous system (CNS) for childhood cancer. METHODS AND MATERIALS: We retrospectively identified 10 patients aged ≤19 years who received radiotherapy to sites in the craniospinal axis and subsequently developed a meningioma. We report the histology of the radiation-induced meningioma, treatment received, and ultimate outcome among this cohort of patients. RESULTS: Meningioma was diagnosed at a median of 23.5 years after completion of the primary radiation. Fifty percent of second meningiomas were World Health Organization Grade 2 (atypical) or higher. All cases were managed with a single modality: resection alone (n = 7), fractionated radiotherapy (n = 2), and stereotactic radiosurgery (n = 1). The actuarial event-free survival and overall survival rate at 5 years after treatment for a radiation-induced meningioma was 89%. Three patients who underwent resection for retreatment experienced a Grade 3 toxicity. CONCLUSIONS: Radiation-induced meningiomas after treatment of pediatric CNS tumors are effectively managed with single-modality therapy. Such late-effect data inform the overall therapeutic ratio and support the continued role of selective irradiation in managing pediatric CNS malignancies.
PURPOSE: To report the outcome of patients treated at the University of Florida who developed meningiomas after radiation to the central nervous system (CNS) for childhood cancer. METHODS AND MATERIALS: We retrospectively identified 10 patients aged ≤19 years who received radiotherapy to sites in the craniospinal axis and subsequently developed a meningioma. We report the histology of the radiation-induced meningioma, treatment received, and ultimate outcome among this cohort of patients. RESULTS:Meningioma was diagnosed at a median of 23.5 years after completion of the primary radiation. Fifty percent of second meningiomas were World Health Organization Grade 2 (atypical) or higher. All cases were managed with a single modality: resection alone (n = 7), fractionated radiotherapy (n = 2), and stereotactic radiosurgery (n = 1). The actuarial event-free survival and overall survival rate at 5 years after treatment for a radiation-induced meningioma was 89%. Three patients who underwent resection for retreatment experienced a Grade 3 toxicity. CONCLUSIONS: Radiation-induced meningiomas after treatment of pediatric CNS tumors are effectively managed with single-modality therapy. Such late-effect data inform the overall therapeutic ratio and support the continued role of selective irradiation in managing pediatric CNS malignancies.
Authors: Elvis Terci Valera; Sabrine Teixeira Ferraz; María Sol Brassesco; Xiumei Zhen; Yiping Shen; Antonio Carlos dos Santos; Luciano Neder; Ricardo Santos Oliveira; Carlos Alberto Scrideli; Luiz Gonzaga Tone Journal: Childs Nerv Syst Date: 2013-10-03 Impact factor: 1.475
Authors: María Sol Brassesco; Elvis Terci Valera; Luciano Neder; Julia Alejandra Pezuk; Ricardo Santos Oliveira; Carlos Alberto Scrideli; Luiz Gonzaga Tone Journal: J Neurooncol Date: 2012-10-18 Impact factor: 4.130
Authors: Peter F Morgenstern; Kalee Shah; Ira J Dunkel; Anne S Reiner; Yasmin Khakoo; Marc K Rosenblum; Philip Gutin Journal: J Clin Neurosci Date: 2016-04-08 Impact factor: 1.961
Authors: Conor S Gillespie; Abdurrahman I Islim; Basel A Taweel; Christopher P Millward; Siddhant Kumar; Nitika Rathi; Shaveta Mehta; Brian J Haylock; Nicola Thorp; Catherine E Gilkes; David D A Lawson; Samantha J Mills; Emmanuel Chavredakis; Jibril Osman Farah; Andrew R Brodbelt; Michael D Jenkinson Journal: J Neurooncol Date: 2021-04-22 Impact factor: 4.130