Literature DB >> 29293444

Impact of epigenetics in aging and age related neurodegenerative diseases.

Omkaram Gangisetty1, Miguel A Cabrera2, Sengottuvelan Murugan2.   

Abstract

Epigenetics involves multiple processes such as DNA methylation, histone code modifications, and noncoding RNAs to regulate gene expression. In recent years the implications of epigenetic mechanisms have emerged in the field of neuroscience especially in brain development, memory, learning, and various cognition processes. Epigenetics also plays a pivotal role during the aging process of the brain which has led to various age-related neurodegenerative diseases. This manuscript portrays the findings of various epigenetic mechanisms that play a critical role and their implications in aging as well as  age-related neurodegenerative disorders such as Alzheimer's disease, Parkinson's disease, and Huntington's disease.

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Year:  2018        PMID: 29293444     DOI: 10.2741/4654

Source DB:  PubMed          Journal:  Front Biosci (Landmark Ed)        ISSN: 2768-6698


  7 in total

Review 1.  Circular RNAs: Emblematic Players of Neurogenesis and Neurodegeneration.

Authors:  Marianna D'Anca; Francesca R Buccellato; Chiara Fenoglio; Daniela Galimberti
Journal:  Int J Mol Sci       Date:  2022-04-08       Impact factor: 6.208

2.  QSER1 protects DNA methylation valleys from de novo methylation.

Authors:  Gary Dixon; Heng Pan; Dapeng Yang; Bess P Rosen; Therande Jashari; Nipun Verma; Julian Pulecio; Inbal Caspi; Kihyun Lee; Stephanie Stransky; Abigail Glezer; Chang Liu; Marco Rivas; Ritu Kumar; Yahui Lan; Ingrid Torregroza; Chuan He; Simone Sidoli; Todd Evans; Olivier Elemento; Danwei Huangfu
Journal:  Science       Date:  2021-04-09       Impact factor: 47.728

Review 3.  Mitoepigenetics and Neurodegenerative Diseases.

Authors:  Fabio Coppedè; Andrea Stoccoro
Journal:  Front Endocrinol (Lausanne)       Date:  2019-02-19       Impact factor: 5.555

Review 4.  From molecular promise to preclinical results: HDAC inhibitors in the race for healthy aging drugs.

Authors:  Rebecca L McIntyre; Eileen G Daniels; Marte Molenaars; Riekelt H Houtkooper; Georges E Janssens
Journal:  EMBO Mol Med       Date:  2019-08-01       Impact factor: 12.137

Review 5.  DNA hypermethylation in disease: mechanisms and clinical relevance.

Authors:  Melanie Ehrlich
Journal:  Epigenetics       Date:  2019-07-08       Impact factor: 4.528

6.  The effects of early-life growth hormone intervention on tissue specific histone H3 modifications in long-lived Ames dwarf mice.

Authors:  Fang Zhang; Mert Icyuz; Andrzej Bartke; Liou Y Sun
Journal:  Aging (Albany NY)       Date:  2020-12-28       Impact factor: 5.682

Review 7.  Neurodegenerative movement disorders: An epigenetics perspective and promise for the future.

Authors:  Megha Murthy; Yun Yung Cheng; Janice L Holton; Conceição Bettencourt
Journal:  Neuropathol Appl Neurobiol       Date:  2021-08-05       Impact factor: 6.250

  7 in total

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