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Literature DB >> 29292507

CrossTalk opposing view: lack of evidence supporting an astrocyte-to-neuron lactate shuttle coupling neuronal activity to glucose utilisation in the brain.

Lasse K Bak¹, Anne B Walls¹.

Abstract

Entities: Chemical

Keywords: Astrocyte; Lactate; Neuron

Mesh：

Substances：
Lactic Acid
Glucose

Year: 2018 PMID： 29292507 PMCID： PMC5792606 DOI： 10.1113/JP274945

Source DB: PubMed Journal: J Physiol ISSN： 0022-3751 Impact factor: 5.182

× No keyword cloud information.

22 in total

1. High brain lactate is not caused by a shift in the lactate dehydrogenase A/B ratio.

Authors: Bjørn Quistorff; Niels Grunnet
Journal: Proc Natl Acad Sci U S A Date: 2011-01-28 Impact factor: 11.205

2. Selective distribution of lactate dehydrogenase isoenzymes in neurons and astrocytes of human brain.

Authors: P G Bittar; Y Charnay; L Pellerin; C Bouras; P J Magistretti
Journal: J Cereb Blood Flow Metab Date: 1996-11 Impact factor: 6.200

3. Cerebral oxygen/glucose ratio is low during sensory stimulation and rises above normal during recovery: excess glucose consumption during stimulation is not accounted for by lactate efflux from or accumulation in brain tissue.

Authors: P L Madsen; N F Cruz; L Sokoloff; G A Dienel
Journal: J Cereb Blood Flow Metab Date: 1999-04 Impact factor: 6.200

4. Glutamate uptake into astrocytes stimulates aerobic glycolysis: a mechanism coupling neuronal activity to glucose utilization.

Authors: L Pellerin; P J Magistretti
Journal: Proc Natl Acad Sci U S A Date: 1994-10-25 Impact factor: 11.205

5. Calcium signaling in brain mitochondria: interplay of malate aspartate NADH shuttle and calcium uniporter/mitochondrial dehydrogenase pathways.

Authors: Laura Contreras; Jorgina Satrústegui
Journal: J Biol Chem Date: 2009-01-07 Impact factor: 5.157

6. Neuronal Stimulation Triggers Neuronal Glycolysis and Not Lactate Uptake.

Authors: Carlos Manlio Díaz-García; Rebecca Mongeon; Carolina Lahmann; Dorothy Koveal; Hannah Zucker; Gary Yellen
Journal: Cell Metab Date: 2017-08-01 Impact factor: 27.287

7. Direct evidence for activity-dependent glucose phosphorylation in neurons with implications for the astrocyte-to-neuron lactate shuttle.

Authors: Anant B Patel; James C K Lai; Golam M I Chowdhury; Fahmeed Hyder; Douglas L Rothman; Robert G Shulman; Kevin L Behar
Journal: Proc Natl Acad Sci U S A Date: 2014-03-26 Impact factor: 11.205

8. The isoenzyme pattern of LDH does not play a physiological role; except perhaps during fast transitions in energy metabolism.

Authors: Bjørn Quistorff; Niels Grunnet
Journal: Aging (Albany NY) Date: 2011-05 Impact factor: 5.682

9. Direct neuronal glucose uptake heralds activity-dependent increases in cerebral metabolism.

Authors: Iben Lundgaard; Baoman Li; Lulu Xie; Hongyi Kang; Simon Sanggaard; John D R Haswell; Wei Sun; Siri Goldman; Solomiya Blekot; Michael Nielsen; Takahiro Takano; Rashid Deane; Maiken Nedergaard
Journal: Nat Commun Date: 2015-04-23 Impact factor: 14.919

Review 10. Fluxes of lactate into, from, and among gap junction-coupled astrocytes and their interaction with noradrenaline.

Authors: Leif Hertz; Marie E Gibbs; Gerald A Dienel
Journal: Front Neurosci Date: 2014-09-09 Impact factor: 4.677

28 in total

Review 1. Fluorescent Biosensors for Neuronal Metabolism and the Challenges of Quantitation.

Authors: Dorothy Koveal; Carlos Manlio Díaz-García; Gary Yellen
Journal: Curr Opin Neurobiol Date: 2020-06-16 Impact factor: 6.627

2. Quantitative in vivo imaging of neuronal glucose concentrations with a genetically encoded fluorescence lifetime sensor.

Authors: Carlos Manlio Díaz-García; Carolina Lahmann; Juan Ramón Martínez-François; Binsen Li; Dorothy Koveal; Nidhi Nathwani; Mahia Rahman; Jacob P Keller; Jonathan S Marvin; Loren L Looger; Gary Yellen
Journal: J Neurosci Res Date: 2019-05-20 Impact factor: 4.164

CrossTalk opposing view: lack of evidence supporting an astrocyte-to-neuron lactate shuttle coupling neuronal activity to glucose utilisation in the brain.

1. High brain lactate is not caused by a shift in the lactate dehydrogenase A/B ratio.

2. Selective distribution of lactate dehydrogenase isoenzymes in neurons and astrocytes of human brain.

3. Cerebral oxygen/glucose ratio is low during sensory stimulation and rises above normal during recovery: excess glucose consumption during stimulation is not accounted for by lactate efflux from or accumulation in brain tissue.

4. Glutamate uptake into astrocytes stimulates aerobic glycolysis: a mechanism coupling neuronal activity to glucose utilization.

5. Calcium signaling in brain mitochondria: interplay of malate aspartate NADH shuttle and calcium uniporter/mitochondrial dehydrogenase pathways.

6. Neuronal Stimulation Triggers Neuronal Glycolysis and Not Lactate Uptake.

7. Direct evidence for activity-dependent glucose phosphorylation in neurons with implications for the astrocyte-to-neuron lactate shuttle.

8. The isoenzyme pattern of LDH does not play a physiological role; except perhaps during fast transitions in energy metabolism.

9. Direct neuronal glucose uptake heralds activity-dependent increases in cerebral metabolism.

Review 10. Fluxes of lactate into, from, and among gap junction-coupled astrocytes and their interaction with noradrenaline.

Review 1. Fluorescent Biosensors for Neuronal Metabolism and the Challenges of Quantitation.

2. Quantitative in vivo imaging of neuronal glucose concentrations with a genetically encoded fluorescence lifetime sensor.

Review 3. The Response to Stimulation in Neurons and Astrocytes.

Review 4. Lactate in the brain: from metabolic end-product to signalling molecule.

5. Rebuttal from L. F. Barros and B. Weber.

6. Aerobic Glycolysis in the Brain: Warburg and Crabtree Contra Pasteur.

Review 7. Astrocytes in depression and Alzheimer's disease.

8. Essential Roles of Lactate in Müller Cell Survival and Function.

9. Glucose and lactate as metabolic constraints on presynaptic transmission at an excitatory synapse.

Review 10. Dysregulation of Astrocyte Ion Homeostasis and Its Relevance for Stroke-Induced Brain Damage.