Dynamics and Ultradian Structure of Human Sleep in Real Life.

The temporal dynamics that characterize sleep are difficult to capture outside the sleep laboratory. Therefore, longitudinal studies and big-data approaches assessing sleep dynamics are lacking. Here, we present the first large-scale analysis of human sleep dynamics in real life by making use of longitudinal wrist movement recordings of >16,000 sleep bouts from 573 subjects. Through non-linear conversion of locomotor activity to "Locomotor Inactivity During Sleep" (LIDS), movement patterns are exposed that directly reflect ultradian sleep cycles and replicate the dynamics of laboratory sleep parameters. Our current analyses indicate no sex differences in LIDS-derived sleep dynamics, whereas especially age but also shift work have pronounced effects, specifically on decline rates and ultradian amplitude. In contrast, ultradian period and phase emerged as remarkably stable across the tested variables. Our approach and results provide the necessary quantitative sleep phenotypes for large field studies and outcome assessments in clinical trials.