Nitin Shivappa1, James R Hébert2, Lisa E Paddock3, Lorna Rodriguez-Rodriguez4, Sara H Olson5, Elisa V Bandera6. 1. South Carolina Statewide Cancer Prevention and Control Program, University of South Carolina, Columbia, South Carolina, USA; Department of Epidemiology and Biostatistics, Arnold School of Public Health, University of South Carolina, Columbia, South Carolina, USA. Electronic address: Shivappa@mailbox.sc.edu. 2. South Carolina Statewide Cancer Prevention and Control Program, University of South Carolina, Columbia, South Carolina, USA; Department of Epidemiology and Biostatistics, Arnold School of Public Health, University of South Carolina, Columbia, South Carolina, USA. 3. Cancer Surveillance Research Program, Rutgers Cancer Institute of New Jersey, New Brunswick, New Jersey, USA; Department of Epidemiology, Rutgers School of Public Health, Piscataway, New Jersey, USA. 4. Division of Gynecologic Oncology, Rutgers Cancer Institute of New Jersey, New Brunswick, New Jersey, USA. 5. Department of Epidemiology, Memorial Sloan Kettering Cancer Center, New York, New York, USA. 6. Department of Epidemiology, Rutgers School of Public Health, Piscataway, New Jersey, USA; Population Sciences, Rutgers Cancer Institute of New Jersey, New Brunswick, New Jersey, USA.
Abstract
OBJECTIVE: Diet may influence the development of ovarian cancer. Although it has been shown that inflammation plays an important etiologic role in ovarian carcinogenesis, little is known about the influence of the inflammatory potential of food consumption. The aim of this study was to evaluate the effect of a proinflammatory diet, as indicated by a high dietary inflammatory index (DII®) score, on ovarian cancer risk, in a New Jersey population. METHODS: Data from a case-control study conducted in New Jersey were used to estimate the relation between DII score and the risk for ovarian cancer. The study consisted of 205 cases with incident, histologically confirmed ovarian cancer, and 390 controls identified by random-digit dialing, based on Centers for Medicare & Medicaid Service lists, and area sampling. Computation of the DII was based on the intake of selected dietary factors assessed by a validated food frequency questionnaire (FFQ). Logistic regression models were fit to estimate odds ratios (ORs) and 95% confidence intervals (CIs) adjusted for potential covariates. RESULTS: Although there was no significant association observed in pre- and perimenopausal women, a significant association was observed between the most proinflammatory DII scores and ovarian cancer among postmenopausal women (ORQuartile4 vs1, 1.89; 95% CI, 1.02-3.52; Ptrend = 0.03). CONCLUSION: Findings from the present study suggested that a proinflammatory diet may increase risk for ovarian cancer among postmenopausal women, and warrants further study to confirm this association.
OBJECTIVE: Diet may influence the development of ovarian cancer. Although it has been shown that inflammation plays an important etiologic role in ovarian carcinogenesis, little is known about the influence of the inflammatory potential of food consumption. The aim of this study was to evaluate the effect of a proinflammatory diet, as indicated by a high dietary inflammatory index (DII®) score, on ovarian cancer risk, in a New Jersey population. METHODS: Data from a case-control study conducted in New Jersey were used to estimate the relation between DII score and the risk for ovarian cancer. The study consisted of 205 cases with incident, histologically confirmed ovarian cancer, and 390 controls identified by random-digit dialing, based on Centers for Medicare & Medicaid Service lists, and area sampling. Computation of the DII was based on the intake of selected dietary factors assessed by a validated food frequency questionnaire (FFQ). Logistic regression models were fit to estimate odds ratios (ORs) and 95% confidence intervals (CIs) adjusted for potential covariates. RESULTS: Although there was no significant association observed in pre- and perimenopausal women, a significant association was observed between the most proinflammatory DII scores and ovarian cancer among postmenopausal women (ORQuartile4 vs1, 1.89; 95% CI, 1.02-3.52; Ptrend = 0.03). CONCLUSION: Findings from the present study suggested that a proinflammatory diet may increase risk for ovarian cancer among postmenopausal women, and warrants further study to confirm this association.
Authors: Nitin Shivappa; Anna E Prizment; Cindy K Blair; David R Jacobs; Susan E Steck; James R Hébert Journal: Cancer Epidemiol Biomarkers Prev Date: 2014-08-25 Impact factor: 4.254
Authors: Fred K Tabung; Susan E Steck; Jiajia Zhang; Yunsheng Ma; Angela D Liese; Ilir Agalliu; Melanie Hingle; Lifang Hou; Thomas G Hurley; Li Jiao; Lisa W Martin; Amy E Millen; Hannah L Park; Milagros C Rosal; James M Shikany; Nitin Shivappa; Judith K Ockene; James R Hebert Journal: Ann Epidemiol Date: 2015-03-19 Impact factor: 3.797
Authors: Michael D Wirth; James Burch; Nitin Shivappa; John M Violanti; Cecil M Burchfiel; Desta Fekedulegn; Michael E Andrew; Tara A Hartley; Diane B Miller; Anna Mnatsakanova; Luenda E Charles; Susan E Steck; Thomas G Hurley; John E Vena; James R Hébert Journal: J Occup Environ Med Date: 2014-09 Impact factor: 2.162
Authors: Nitin Shivappa; Antonella Zucchetto; Maurizio Montella; Diego Serraino; Susan E Steck; Carlo La Vecchia; James R Hébert Journal: Br J Nutr Date: 2015-06-08 Impact factor: 3.718
Authors: Nitin Shivappa; Susan E Steck; Thomas G Hurley; James R Hussey; Yunsheng Ma; Ira S Ockene; Fred Tabung; James R Hébert Journal: Public Health Nutr Date: 2013-10-10 Impact factor: 4.022
Authors: Dina Gifkins; Sara H Olson; Lisa Paddock; Melony King; Kitaw Demissie; Shou-En Lu; Ah-Ng Tony Kong; Lorna Rodriguez-Rodriguez; Elisa V Bandera Journal: BMC Cancer Date: 2012-06-01 Impact factor: 4.430
Authors: Lauren C Peres; James R Hebert; Bo Qin; Kristin A Guertin; Elisa V Bandera; Nitin Shivappa; Tareq F Camacho; Deanna Chyn; Anthony J Alberg; Jill S Barnholtz-Sloan; Melissa L Bondy; Michele L Cote; Ellen Funkhouser; Patricia G Moorman; Edward S Peters; Ann G Schwartz; Paul D Terry; Joellen M Schildkraut Journal: J Nutr Date: 2019-09-01 Impact factor: 4.798
Authors: Catherine M Phillips; Ling-Wei Chen; Barbara Heude; Jonathan Y Bernard; Nicholas C Harvey; Liesbeth Duijts; Sara M Mensink-Bout; Kinga Polanska; Giulia Mancano; Matthew Suderman; Nitin Shivappa; James R Hébert Journal: Nutrients Date: 2019-08-12 Impact factor: 5.717