Vanessa Nesi-Reis1, Daniele Stéfanie Sara Lopes Lera-Nonose2, Jully Oyama3, Marielle Priscila Paula Silva-Lalucci4, Izabel Galhardo Demarchi5, Sandra Mara Alessi Aristides6, Jorge Juarez Vieira Teixeira7, Thaís Gomes Verzignassi Silveira8, Maria Valdrinez Campana Lonardoni9. 1. Graduate Program in Health Sciences, Universidade Estadual de Maringá, Avenida Colombo, 5790, Jardim Universitário, CEP 87020-900, Maringá, Paraná, Brazil. Electronic address: pg53003@uem.br. 2. Graduate Program in Health Sciences, Universidade Estadual de Maringá, Avenida Colombo, 5790, Jardim Universitário, CEP 87020-900, Maringá, Paraná, Brazil. Electronic address: pg49348@uem.br. 3. Graduate Program in Bioscience and Physiopathology, Universidade Estadual de Maringá, Avenida Colombo, 5790, Jardim Universitário, CEP 87020-900, Maringá, Paraná, Brazil. Electronic address: pg53406@uem.br. 4. Graduate Program in Bioscience and Physiopathology, Universidade Estadual de Maringá, Avenida Colombo, 5790, Jardim Universitário, CEP 87020-900, Maringá, Paraná, Brazil. Electronic address: marielle.silva@unicesumar.edu.br. 5. Departament of Clinical Analysis and Biomedicine, Universidade Estadual de Maringá, Avenida Colombo, 5790, Jardim Universitário, CEP 87020-900, Maringá, Paraná, Brazil. Electronic address: igdemarchi2@uem.com.br. 6. Departament of Clinical Analysis and Biomedicine, Universidade Estadual de Maringá, Avenida Colombo, 5790, Jardim Universitário, CEP 87020-900, Maringá, Paraná, Brazil. Electronic address: smaaristides@uem.br. 7. Departament of Clinical Analysis and Biomedicine, Universidade Estadual de Maringá, Avenida Colombo, 5790, Jardim Universitário, CEP 87020-900, Maringá, Paraná, Brazil. Electronic address: jjvteixeira@uem.br. 8. Departament of Clinical Analysis and Biomedicine, Universidade Estadual de Maringá, Avenida Colombo, 5790, Jardim Universitário, CEP 87020-900, Maringá, Paraná, Brazil. Electronic address: tgvsilveira@uem.br. 9. Departament of Clinical Analysis and Biomedicine, Universidade Estadual de Maringá, Avenida Colombo, 5790, Jardim Universitário, CEP 87020-900, Maringá, Paraná, Brazil. Electronic address: mvclonardoni@uem.br.
Abstract
OBJECTIVE: We researched articles that used photodynamic therapy (PDT) for skin wound healing in humans. METHODS: The systematic review was conducted through scientific articles that investigated the action of PDT on wound healing in humans, published from July 2005 to March 2017, in the data bases PubMed and LILACS. RESULTS: The main types of wound described in selected articles in this review were chronic ulcer and non-melanoma skin cancer. For accomplishing the PDT, second generation of photosensitizing agents with laser or light emitting diode were used. The studies demonstrated that PDT contribute in several ways to the wound healing process: leading to cellular death; reducing or increasing inflammation; stimulating fibroblasts proliferation and, consequently, of collagen and elastin; raising transforming growth factor beta and metalloproteinases. Based on this, PDT provided good results in wound healing process, acting in several steps and accelerating tissue repair. CONCLUSIONS: PDT improved healing in many wound models in humans, revealing itself as a promising therapeutic modality for stimulating wound healing and remodelling.
OBJECTIVE: We researched articles that used photodynamic therapy (PDT) for skin wound healing in humans. METHODS: The systematic review was conducted through scientific articles that investigated the action of PDT on wound healing in humans, published from July 2005 to March 2017, in the data bases PubMed and LILACS. RESULTS: The main types of wound described in selected articles in this review were chronic ulcer and non-melanoma skin cancer. For accomplishing the PDT, second generation of photosensitizing agents with laser or light emitting diode were used. The studies demonstrated that PDT contribute in several ways to the wound healing process: leading to cellular death; reducing or increasing inflammation; stimulating fibroblasts proliferation and, consequently, of collagen and elastin; raising transforming growth factor beta and metalloproteinases. Based on this, PDT provided good results in wound healing process, acting in several steps and accelerating tissue repair. CONCLUSIONS: PDT improved healing in many wound models in humans, revealing itself as a promising therapeutic modality for stimulating wound healing and remodelling.
Authors: Tao Yang; Yang Tan; Wentao Zhang; Weijiang Yang; Jiefu Luo; Ling Chen; Hong Liu; Guihong Yang; Xia Lei Journal: Front Cell Dev Biol Date: 2020-12-04
Authors: Hala Zuhayri; Viktor V Nikolaev; Anastasia I Knyazkova; Tatiana B Lepekhina; Natalya A Krivova; Valery V Tuchin; Yury V Kistenev Journal: Pharmaceutics Date: 2022-01-26 Impact factor: 6.321