The diagnostic performance of densitometry is inadequate. New techniques of non-invasive evaluation of bone quality may improve fracture risk prediction. Testing the value of these techniques is the goal of the QUALYOR cohort. INTRODUCTION: The bone mineral density (BMD) of postmenopausal women who sustain osteoporotic fracture is generally above the World Health Organization definition for osteoporosis. Therefore, new approaches to improve the detection of women at high risk for fracture are warranted. METHODS: We have designed and recruited a new cohort to assess the predictive value of several techniques to assess bone quality, including high-resolution peripheral quantitative computerized tomography (HRpQCT), hip QCT, calcaneus texture analysis, and biochemical markers. We have enrolled 1575 postmenopausal women, aged at least 50, with an areal BMD femoral neck or lumbar spine T-score between - 1.0 and - 3.0. Clinical risk factors for fracture have been collected along with serum and blood samples. RESULTS: We describe the design of the QUALYOR study. Among these 1575 women, 80% were aged at least 60. The mean femoral neck T-score was - 1.6 and the mean lumbar spine T-score was -1.2. This cohort is currently being followed up. CONCLUSIONS: QUALYOR will provide important information on the relationship between bone quality variables and fracture risk in women with moderately decreased BMD.
The diagnostic performance of densitometry is inadequate. New techniques of non-invasive evaluation of bone quality may improve fracture risk prediction. Testing the value of these techniques is the goal of the QUALYOR cohort. INTRODUCTION: The bone mineral density (BMD) of postmenopausal women who sustain osteoporotic fracture is generally above the World Health Organization definition for osteoporosis. Therefore, new approaches to improve the detection of women at high risk for fracture are warranted. METHODS: We have designed and recruited a new cohort to assess the predictive value of several techniques to assess bone quality, including high-resolution peripheral quantitative computerized tomography (HRpQCT), hip QCT, calcaneus texture analysis, and biochemical markers. We have enrolled 1575 postmenopausal women, aged at least 50, with an areal BMD femoral neck or lumbar spine T-score between - 1.0 and - 3.0. Clinical risk factors for fracture have been collected along with serum and blood samples. RESULTS: We describe the design of the QUALYOR study. Among these 1575 women, 80% were aged at least 60. The mean femoral neck T-score was - 1.6 and the mean lumbar spine T-score was -1.2. This cohort is currently being followed up. CONCLUSIONS: QUALYOR will provide important information on the relationship between bone quality variables and fracture risk in women with moderately decreased BMD.
Authors: Elizabeth J Samelson; Kerry E Broe; Hanfei Xu; Laiji Yang; Steven Boyd; Emmanuel Biver; Pawel Szulc; Jonathan Adachi; Shreyasee Amin; Elizabeth Atkinson; Claudie Berger; Lauren Burt; Roland Chapurlat; Thierry Chevalley; Serge Ferrari; David Goltzman; David A Hanley; Marian T Hannan; Sundeep Khosla; Ching-Ti Liu; Mattias Lorentzon; Dan Mellstrom; Blandine Merle; Maria Nethander; René Rizzoli; Elisabeth Sornay-Rendu; Bert Van Rietbergen; Daniel Sundh; Andy Kin On Wong; Claes Ohlsson; Serkalem Demissie; Douglas P Kiel; Mary L Bouxsein Journal: Lancet Diabetes Endocrinol Date: 2018-11-28 Impact factor: 32.069
Authors: Danielle E Whittier; Elizabeth J Samelson; Marian T Hannan; Lauren A Burt; David A Hanley; Emmanuel Biver; Pawel Szulc; Elisabeth Sornay-Rendu; Blandine Merle; Roland Chapurlat; Eric Lespessailles; Andy Kin On Wong; David Goltzman; Sundeep Khosla; Serge Ferrari; Mary L Bouxsein; Douglas P Kiel; Steven K Boyd Journal: J Bone Miner Res Date: 2022-01-14 Impact factor: 6.390
Authors: Roland Chapurlat; Minh Bui; Elisabeth Sornay-Rendu; Roger Zebaze; Pierre D Delmas; Danny Liew; Eric Lespessailles; Ego Seeman Journal: J Bone Miner Res Date: 2019-12-10 Impact factor: 6.390