Ravi Retnakaran1,2,3, Shi Wu Wen4,5,6,7, Hongzhuan Tan7, Shujin Zhou8, Chang Ye1, Minxue Shen4,5,6,7, Graeme N Smith9, Mark C Walker4,5,6. 1. Leadership Sinai Centre for Diabetes, Mount Sinai Hospital, Toronto, Ontario, Canada. 2. Division of Endocrinology, University of Toronto, Toronto, Ontario, Canada. 3. Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada. 4. OMNI Research Group, Department of Obstetrics and Gynecology, University of Ottawa, Ottawa, Ontario, Canada. 5. Ottawa Hospital Research Institute, Clinical Epidemiology Program, Ottawa, Ontario, Canada. 6. Department of Epidemiology and Community Medicine, University of Ottawa, Ottawa, Ontario, Canada. 7. School of Public Health, Central South University, Changsha, China. 8. Liuyang Municipal Hospital of Maternal and Child Health, Beizheng, Liuyang, China. 9. Queen's Perinatal Research Unit, Department of Obstetrics and Gynecology, Queen's University, Kingston, Ontario, Canada.
Abstract
Importance: Gestational weight gain is a determinant of infant birth weight, but it is unclear whether its timing in pregnancy may hold implications in this regard. Previous studies have yielded conflicting findings on the association of maternal weight gain in early pregnancy with birth weight. However, as these studies have typically recruited women during the first trimester, they are inherently limited by a reliance on self-reported pregravid weight. Objective: To evaluate the associations of directly measured maternal pregravid weight and the timing of subsequent weight gain across pregnancy with infant birth weight. Design, Setting, and Participants: In this prospective, preconception, observational cohort study, 1164 newly married women in Liuyang, China, underwent pregravid evaluation at a median of 19.9 weeks before a singleton pregnancy during which they underwent serial weight measurements. The study was conducted from February 1, 2009, to November 4, 2015. Data analysis was performed between September 1, 2016, and May 6, 2017. Exposure: Maternal weight gain was calculated for the following 10 gestational intervals: from pregravid to less than 14, 14 to 18, 19 to 23, 24 to 28, 29 to 30, 31 to 32, 33 to 34, 35 to 36, 37 to 38, and 39 to 40 weeks. Main Outcomes and Measures: Associations of pregravid weight and weight gain within each of the 10 gestational intervals with the outcome of infant birth weight. Results: The mean (SD) age of the 1164 women included in the study was 25.3 (3.1) years. Pregravid weight was consistently associated with infant birth weight. However, among the 10 gestational intervals, only weight gain from pregravid to 14 weeks and from 14 to 18 weeks was associated with birth weight. Birth weight increased by 13.6 g/kg (95% CI, 3.2-24.1 g/kg) of maternal weight gain from pregravid to 14 weeks and by 26.1 g/kg (95% CI, 3.8-48.4 g/kg) of maternal weight gain from 14 to 18 weeks. Conclusion and Relevance: Maternal weight only in the first half of gestation is a determinant of infant birth weight. Before pregnancy and early gestation may be a critical window for intervention to affect subsequent birth weight.
Importance: Gestational weight gain is a determinant of infant birth weight, but it is unclear whether its timing in pregnancy may hold implications in this regard. Previous studies have yielded conflicting findings on the association of maternal weight gain in early pregnancy with birth weight. However, as these studies have typically recruited women during the first trimester, they are inherently limited by a reliance on self-reported pregravid weight. Objective: To evaluate the associations of directly measured maternal pregravid weight and the timing of subsequent weight gain across pregnancy with infant birth weight. Design, Setting, and Participants: In this prospective, preconception, observational cohort study, 1164 newly married women in Liuyang, China, underwent pregravid evaluation at a median of 19.9 weeks before a singleton pregnancy during which they underwent serial weight measurements. The study was conducted from February 1, 2009, to November 4, 2015. Data analysis was performed between September 1, 2016, and May 6, 2017. Exposure: Maternal weight gain was calculated for the following 10 gestational intervals: from pregravid to less than 14, 14 to 18, 19 to 23, 24 to 28, 29 to 30, 31 to 32, 33 to 34, 35 to 36, 37 to 38, and 39 to 40 weeks. Main Outcomes and Measures: Associations of pregravid weight and weight gain within each of the 10 gestational intervals with the outcome of infant birth weight. Results: The mean (SD) age of the 1164 women included in the study was 25.3 (3.1) years. Pregravid weight was consistently associated with infant birth weight. However, among the 10 gestational intervals, only weight gain from pregravid to 14 weeks and from 14 to 18 weeks was associated with birth weight. Birth weight increased by 13.6 g/kg (95% CI, 3.2-24.1 g/kg) of maternal weight gain from pregravid to 14 weeks and by 26.1 g/kg (95% CI, 3.8-48.4 g/kg) of maternal weight gain from 14 to 18 weeks. Conclusion and Relevance: Maternal weight only in the first half of gestation is a determinant of infant birth weight. Before pregnancy and early gestation may be a critical window for intervention to affect subsequent birth weight.
Authors: Ravi Retnakaran; Shi Wu Wen; Hongzhuan Tan; Shujin Zhou; Chang Ye; Minxue Shen; Graeme N Smith; Mark C Walker Journal: Am J Hypertens Date: 2017-04-01 Impact factor: 2.689
Authors: Anne P Starling; John T Brinton; Deborah H Glueck; Allison L Shapiro; Curtis S Harrod; Anne M Lynch; Anna Maria Siega-Riz; Dana Dabelea Journal: Am J Clin Nutr Date: 2014-12-03 Impact factor: 7.045
Authors: Lucilla Poston; Ruth Bell; Helen Croker; Angela C Flynn; Keith M Godfrey; Louise Goff; Louise Hayes; Nina Khazaezadeh; Scott M Nelson; Eugene Oteng-Ntim; Dharmintra Pasupathy; Nashita Patel; Stephen C Robson; Jane Sandall; Thomas A B Sanders; Naveed Sattar; Paul T Seed; Jane Wardle; Melissa K Whitworth; Annette L Briley Journal: Lancet Diabetes Endocrinol Date: 2015-07-09 Impact factor: 32.069
Authors: Leila Cheikh Ismail; Deborah C Bishop; Ruyan Pang; Eric O Ohuma; Gilberto Kac; Barbara Abrams; Kathleen Rasmussen; Fernando C Barros; Jane E Hirst; Ann Lambert; Aris T Papageorghiou; William Stones; Yasmin A Jaffer; Douglas G Altman; J Alison Noble; Maria Rosa Giolito; Michael G Gravett; Manorama Purwar; Stephen H Kennedy; Zulfiqar A Bhutta; José Villar Journal: BMJ Date: 2016-02-29
Authors: Teresa A Hillier; Kathryn L Pedula; Keith K Ogasawara; Kimberly K Vesco; Caryn Oshiro; Jan L Van Marter Journal: J Perinat Med Date: 2022-05-11 Impact factor: 2.716
Authors: Teresa A Hillier; Keith K Ogasawara; Kathryn L Pedula; Kimberly K Vesco; Caryn E S Oshiro; Jan L Van Marter Journal: J Womens Health (Larchmt) Date: 2020-04-24 Impact factor: 2.681
Authors: Roslyn Mainland; Shi Wu Wen; Hongzhuan Tan; Shujin Zhou; Chang Ye; Minxue Shen; Graeme N Smith; Mark C Walker; Ravi Retnakaran Journal: Womens Health Rep (New Rochelle) Date: 2021-03-23
Authors: Ravi Retnakaran; Shi Wu Wen; Hongzhuan Tan; Shujin Zhou; Chang Ye; Minxue Shen; Graeme N Smith; Mark C Walker Journal: JAMA Netw Open Date: 2021-12-01
Authors: Simone Kew; Chang Ye; Sadia Mehmood; Anthony J Hanley; Mathew Sermer; Bernard Zinman; Ravi Retnakaran Journal: BMJ Open Diabetes Res Care Date: 2020-02