Muhammed Altinisik1, Arif Koytak2, Ahmet Elbay2, Enes Toklu3, Taha Sezer2, Abdurrahim Kocyigit4. 1. a Department of Ophthalmology , Nevsehir State Hospital , Nevsehir , Turkey. 2. b Faculty of Medicine, Department of Ophthalmology , Bezmialem Vakif University , Istanbul , Turkey. 3. c Department of Ophthalmology , Kemalpasa State Hospital , Izmir , Turkey. 4. d Faculty of Medicine, Department of Biochemistry , Bezmialem Vakif University , Istanbul , Turkey.
Abstract
PURPOSE: To analyze oxidative stress parameters in the aqueous humor with retinal vein occlusion. MATERIALS AND METHODS: A total of 56 patients who underwent cataract surgery were enrolled in this study. The eyes with retinal vein occlusion were included in the study group. Aqueous humor was sampled from all patients and analyzed by an automated measurement method. Total oxidant status (TOS), total antioxidant status (TAS), and oxidative stres index (OSI) were calculated. RESULTS: OSI was significantly higher in the study group (p = 0.04). TAS was significantly lower (p = 0.01) and OSI was significantly higher (p = 0.01) in cases with both central retinal vein occlusion and macular edema. Previous laser photocoalugation to the retina and the duration of disease had no significant effect on the levels of oxidative stress parameters. CONCLUSION: OSI was found higher in patients with retinal vein occlusion. This increase is more significant in patients with macular edema and central retinal vein occlusion; in which TAS was also found to decrease.
PURPOSE: To analyze oxidative stress parameters in the aqueous humor with retinal vein occlusion. MATERIALS AND METHODS: A total of 56 patients who underwent cataract surgery were enrolled in this study. The eyes with retinal vein occlusion were included in the study group. Aqueous humor was sampled from all patients and analyzed by an automated measurement method. Total oxidant status (TOS), total antioxidant status (TAS), and oxidative stres index (OSI) were calculated. RESULTS: OSI was significantly higher in the study group (p = 0.04). TAS was significantly lower (p = 0.01) and OSI was significantly higher (p = 0.01) in cases with both central retinal vein occlusion and macular edema. Previous laser photocoalugation to the retina and the duration of disease had no significant effect on the levels of oxidative stress parameters. CONCLUSION: OSI was found higher in patients with retinal vein occlusion. This increase is more significant in patients with macular edema and central retinal vein occlusion; in which TAS was also found to decrease.
Entities:
Keywords:
Aqueous humor; oxidative stress index; retinal vein occlusion; total antioxidant status; total oxidant status