Literature DB >> 29278824

Metabotropic glutamate receptors: the potential for therapeutic applications in Alzheimer's disease.

Filippo Caraci1, Ferdinando Nicoletti2, Agata Copani3.   

Abstract

A dysfunction of glutamate signaling is implicated at several levels in the pathogenesis of Alzheimer's disease. Currently, metabotropic glutamate receptors, which have a wide distribution in the central nervous system and activate a multitude of cell signaling pathways, are pursued as targets for therapeutic intervention in Alzheimer's disease. Research is still limited, but results underscore the relevance of ongoing studies. Here we discuss the latest updates regarding metabotropic glutamate receptors and their role in Alzheimer's disease, as well as promising metabotropic glutamate receptor ligands that have been investigated in preclinical models of Alzheimer's disease.
Copyright © 2017 Elsevier Ltd. All rights reserved.

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Year:  2017        PMID： 29278824     DOI： 10.1016/j.coph.2017.12.001

Source DB:  PubMed          Journal:  Curr Opin Pharmacol        ISSN： 1471-4892            Impact factor:   5.547


  10 in total

1.  Metabotropic glutamate receptor subtype 5 is altered in LPS-induced murine neuroinflammation model and in the brains of AD and ALS patients.

Authors:  Adrienne Müller Herde; Roger Schibli; Markus Weber; Simon M Ametamey
Journal:  Eur J Nucl Med Mol Imaging       Date:  2018-10-05       Impact factor: 9.236

2.  Reduced uptake of [11C]-ABP688, a PET tracer for metabolic glutamate receptor 5 in hippocampus and amygdala in Alzheimer's dementia.

Authors:  Valerie Treyer; Anton F Gietl; Husam Suliman; Esmeralda Gruber; Rafael Meyer; Andreas Buchmann; Anass Johayem; Paul G Unschuld; Roger M Nitsch; Alfred Buck; Simon M Ametamey; Christoph Hock
Journal:  Brain Behav       Date:  2020-04-18       Impact factor: 2.708

3.  Group II Metabotropic Glutamate Receptors Mediate Presynaptic Inhibition of Excitatory Transmission in Pyramidal Neurons of the Human Cerebral Cortex.

Authors:  Marco Bocchio; Istvan P Lukacs; Richard Stacey; Puneet Plaha; Vasileios Apostolopoulos; Laurent Livermore; Arjune Sen; Olaf Ansorge; Martin J Gillies; Peter Somogyi; Marco Capogna
Journal:  Front Cell Neurosci       Date:  2019-01-08       Impact factor: 5.505

4.  Unchanged type 1 metabotropic glutamate receptor availability in patients with Alzheimer's disease: A study using 11C-ITMM positron emission tomography.

Authors:  Kenji Ishibashi; Yoshiharu Miura; Jun Toyohara; Kiichi Ishiwata; Kenji Ishii
Journal:  Neuroimage Clin       Date:  2019-03-16       Impact factor: 4.881

Review 5.  Functional Neurophysiological Biomarkers of Early-Stage Alzheimer's Disease: A Perspective of Network Hyperexcitability in Disease Progression.

Authors:  Sean Tok; Abdallah Ahnaou; Wilhelmus Drinkenburg
Journal:  J Alzheimers Dis       Date:  2022       Impact factor: 4.160

6.  The Density of Group I mGlu5 Receptors Is Reduced along the Neuronal Surface of Hippocampal Cells in a Mouse Model of Alzheimer's Disease.

Authors:  Alejandro Martín-Belmonte; Carolina Aguado; Rocío Alfaro-Ruiz; José Luis Albasanz; Mairena Martín; Ana Esther Moreno-Martínez; Yugo Fukazawa; Rafael Luján
Journal:  Int J Mol Sci       Date:  2021-05-30       Impact factor: 5.923

Review 7.  Pathophysiological Mechanisms of Cognitive Impairment and Neurodegeneration by Toxoplasma gondii Infection.

Authors:  Gloria Ortiz-Guerrero; Rodrigo E Gonzalez-Reyes; Alejandra de-la-Torre; German Medina-Rincón; Mauricio O Nava-Mesa
Journal:  Brain Sci       Date:  2020-06-12

Review 8.  Metabotropic Glutamate Receptors in Glial Cells: A New Potential Target for Neuroprotection?

Authors:  Simona Federica Spampinato; Agata Copani; Ferdinando Nicoletti; Maria Angela Sortino; Filippo Caraci
Journal:  Front Mol Neurosci       Date:  2018-11-13       Impact factor: 5.639

Review 9.  Family C G-Protein-Coupled Receptors in Alzheimer's Disease and Therapeutic Implications.

Authors:  Ilaria Dal Prà; Ubaldo Armato; Anna Chiarini
Journal:  Front Pharmacol       Date:  2019-10-28       Impact factor: 5.810

10.  Synthesis and preliminary studies of 11C-labeled tetrahydro-1,7-naphthyridine-2-carboxamides for PET imaging of metabotropic glutamate receptor 2.

Authors:  Xiaofei Zhang; Yiding Zhang; Zhen Chen; Tuo Shao; Richard Van; Katsushi Kumata; Xiaoyun Deng; Hualong Fu; Tomoteru Yamasaki; Jian Rong; Kuan Hu; Akiko Hatori; Lin Xie; Qingzhen Yu; Weijian Ye; Hao Xu; Douglas J Sheffler; Nicholas D P Cosford; Yihan Shao; Pingping Tang; Lu Wang; Ming-Rong Zhang; Steven H Liang
Journal:  Theranostics       Date:  2020-09-14       Impact factor: 11.556
  10 in total

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