| Literature DB >> 29278747 |
Marco Antônio Peliky Fontes1, Gisele Cristiane Vaz2, Thais Zielke Dias Cardoso2, Mariana Flávia de Oliveira2, Maria José Campagnole-Santos2, Robson Augusto Souza Dos Santos2, Neeru M Sharma3, Kaushik P Patel3, Frédéric Frézard4.
Abstract
There are multiple challenges for neuropharmacology in the future. Undoubtedly, one of the greatest challenges is the development of strategies for pharmacological targeting of specific brain regions for treatment of diseases. GABA is the main inhibitory neurotransmitter in the central nervous system, and dysfunction of GABAergic mechanisms is associated with different neurological conditions. Liposomes are lipid vesicles that are able to encapsulate chemical compounds and are used for chronic drug delivery. This short review reports our experience with the development of liposomes for encapsulation and chronic delivery of GABA to sites within the brain. Directions for future research regarding the efficacy and practical use of GABA-containing liposomes for extended periods of time as well as understanding and targeting neurological conditions are discussed.Entities:
Keywords: GABA; Liposomes; Nervous system; Neurological diseases; Neuroscience
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Year: 2017 PMID： 29278747 PMCID： PMC6415746 DOI： 10.1016/j.nano.2017.12.007
Source DB: PubMed Journal: Nanomedicine ISSN： 1549-9634 Impact factor: 5.307