Literature DB >> 10202538

Microglia as mediators of inflammatory and degenerative diseases.

F González-Scarano1, G Baltuch.   

Abstract

Microglia are the principal immune cells in the central nervous system (CNS) and have a critical role in host defense against invading microorganisms and neoplastic cells. However, as with immune cells in other organs, microglia may play a dual role, amplifying the effects of inflammation and mediating cellular degeneration as well as protecting the CNS. In entities like human immunodeficiency virus (HIV) infection of the nervous system, microglia are also critical to viral persistence. In this review we discuss the role of microglia in three diseases in which their activity is at least partially deleterious: HIV, multiple sclerosis, and Alzheimer's disease.

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Year:  1999        PMID： 10202538     DOI： 10.1146/annurev.neuro.22.1.219

Source DB:  PubMed          Journal:  Annu Rev Neurosci        ISSN： 0147-006X            Impact factor:   12.449


  281 in total

1.  Inflammatory responses to amyloidosis in a transgenic mouse model of Alzheimer's disease.

Authors:  Y Matsuoka; M Picciano; B Malester; J LaFrancois; C Zehr; J M Daeschner; J A Olschowka; M I Fonseca; M K O'Banion; A J Tenner; C A Lemere; K Duff
Journal:  Am J Pathol       Date:  2001-04       Impact factor: 4.307

2.  Distinct role for microglia in rotenone-induced degeneration of dopaminergic neurons.

Authors:  Hui-Ming Gao; Jau-Shyong Hong; Wanqin Zhang; Bin Liu
Journal:  J Neurosci       Date:  2002-02-01       Impact factor: 6.167

3.  Cerebrospinal fluid lipoproteins are more vulnerable to oxidation in Alzheimer's disease and are neurotoxic when oxidized ex vivo.

Authors:  C N Bassett; M D Neely; K R Sidell; W R Markesbery; L L Swift; T J Montine
Journal:  Lipids       Date:  1999-12       Impact factor: 1.880

4.  Impact of endogenous nitric oxide on microglial cell energy metabolism and labile iron pool.

Authors:  Benoît Chénais; Hamid Morjani; Jean-Claude Drapier
Journal:  J Neurochem       Date:  2002-05       Impact factor: 5.372

5.  Antibody-mediated inhibition of integrin α5β1 blocks neurotoxic prion peptide PrP106-126-induced activation of BV2 microglia.

Authors:  Jiaxin Chang; Lifeng Yang; Mohammed Kouadir; Yun Peng; Siming Zhang; Fushan Shi; Xiangmei Zhou; Xiaomin Yin; Deming Zhao
Journal:  J Mol Neurosci       Date:  2012-05-31       Impact factor: 3.444

6.  Cannabinoid CB(2) receptors modulate ERK-1/2 kinase signalling and NO release in microglial cells stimulated with bacterial lipopolysaccharide.

Authors:  Stefania Merighi; Stefania Gessi; Katia Varani; Carolina Simioni; Debora Fazzi; Prisco Mirandola; Pier Andrea Borea
Journal:  Br J Pharmacol       Date:  2012-03       Impact factor: 8.739

7.  Thymoquinone increases the expression of neuroprotective proteins while decreasing the expression of pro-inflammatory cytokines and the gene expression NFκB pathway signaling targets in LPS/IFNγ -activated BV-2 microglia cells.

Authors:  Makini K Cobourne-Duval; Equar Taka; Patricia Mendonca; Karam F A Soliman
Journal:  J Neuroimmunol       Date:  2018-05-04       Impact factor: 3.478

8.  Differential expression of doublecortin and microglial markers in the rat brain following fractionated irradiation.

Authors:  Sona Balentova; Eva Hajtmanova; Marian Adamkov; Jan Lehotsky
Journal:  Neurochem Res       Date:  2014-12-09       Impact factor: 3.996

9.  Associative and predictive biomarkers of dementia in HIV-1-infected patients.

Authors:  V V R Bandaru; J C McArthur; N Sacktor; R G Cutler; E L Knapp; M P Mattson; N J Haughey
Journal:  Neurology       Date:  2007-05-01       Impact factor: 9.910

10.  In vitro regulation of rat derived microglia.

Authors:  Valter R M Lombardi; Ignacio Etcheverría; Lucía Fernández-Novoa; Ramón Cacabelos
Journal:  Neurotox Res       Date:  2003       Impact factor: 3.911
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