Yuan-Yuei Chen1, Tung-Wei Kao2, Hui-Fang Yang3, Cheng-Wai Chou4, Chen-Jung Wu5, Ching-Huang Lai6, Yu-Shan Sun3, Chung-Ching Wang4, Wei-Liang Chen7. 1. Department of Internal Medicine, Tri-Service General Hospital Songshan Branch, Taiwan, Republic of China; Division of Family Medicine, Department of Family and Community Medicine, Tri-Service General Hospital, School of Medicine, National Defense Medical Center, Taipei, Taiwan, Republic of China. 2. Division of Family Medicine, Department of Family and Community Medicine, Tri-Service General Hospital, School of Medicine, National Defense Medical Center, Taipei, Taiwan, Republic of China; Division of Geriatric Medicine, Department of Family and Community Medicine, Tri-Service General Hospital, School of Medicine, National Defense Medical Center, Taipei, Taiwan, Republic of China; Graduate Institute of Clinical Medical, College of Medicine, National Taiwan University, Taipei, Taiwan, Republic of China. 3. Division of Family Medicine, Department of Family and Community Medicine, Tri-Service General Hospital, School of Medicine, National Defense Medical Center, Taipei, Taiwan, Republic of China; Division of Geriatric Medicine, Department of Family and Community Medicine, Tri-Service General Hospital, School of Medicine, National Defense Medical Center, Taipei, Taiwan, Republic of China. 4. Division of Family Medicine, Department of Family and Community Medicine, Tri-Service General Hospital, School of Medicine, National Defense Medical Center, Taipei, Taiwan, Republic of China. 5. Division of Family Medicine, Department of Family and Community Medicine, Tri-Service General Hospital, School of Medicine, National Defense Medical Center, Taipei, Taiwan, Republic of China; Division of Geriatric Medicine, Department of Family and Community Medicine, Tri-Service General Hospital, School of Medicine, National Defense Medical Center, Taipei, Taiwan, Republic of China; Division of Family Medicine, Department of Community Medicine, Taoyuan Armed Forces General Hospital, Taoyuan, Taiwan, Republic of China. 6. School of Public Health, National Defense Medical Center, Taipei, Taiwan, Republic of China. 7. Division of Family Medicine, Department of Family and Community Medicine, Tri-Service General Hospital, School of Medicine, National Defense Medical Center, Taipei, Taiwan, Republic of China; Division of Geriatric Medicine, Department of Family and Community Medicine, Tri-Service General Hospital, School of Medicine, National Defense Medical Center, Taipei, Taiwan, Republic of China. Electronic address: m871079@mail.ndmctsgh.edu.tw.
Abstract
BACKGROUND: A growing number of studies are available to shed some light on the association between uric acid (UA) and cardiovascular diseases. However, there have been few studies to support a causal link between UA, metabolic syndrome (MetS), diabetes mellitus (DM) and hypertension (HTN) in young subjects. METHODS: From the Health Examination Registration System of Taiwanese military service during the period 2013-2015, there were 46,561 eligible participants who were 20years old or older in our study. Different analytical steps of analysis were performed to examine the association between UA and cardiometabolic risk using logistic regression, receiver operating characteristic (ROC) curve analysis and Cox regression. RESULTS: For total population, serum UA had significant associations with the presence of MetS (OR=2.08, 95% CI=1.51-2.87), DM (OR=2.59, 95% CI=1.09-6.19) and HTN (OR=1.49, 95% CI=1.07-2.07) in the cross-sectional analysis. According to the cut-off values of UA calculating by the ROC curve analysis in each sex/age subgroup, the association between UA and incident adverse outcomes were analyzed in a longitudinal study. In male, higher UA significantly increased the risks for developing MetS in 30-40years (HR=1.12, 95% CI=1.01-1.25), DM in <30years (HR=2.75, 95% CI=1.38-5.45) and HTN in all subgroups (HR=1.17, 95% CI=1.01-1.37; HR=1.65, 95% CI=1.08-2.53; HR=1.72, 95% CI=1.22-2.43). In females, a higher UA was significantly associated with an increased risk of incident MetS in >40years (HR=2.99, 95% CI=1.34-6.64), HTN in >40years (HR=2.58, 95% CI=1.02-6.55), and no increased risk of DM. CONCLUSIONS: Our study concluded that serum UA is an important predictor for the risk of incident MetS, DM, and HTN in adults, especially in male population.
BACKGROUND: A growing number of studies are available to shed some light on the association between uric acid (UA) and cardiovascular diseases. However, there have been few studies to support a causal link between UA, metabolic syndrome (MetS), diabetes mellitus (DM) and hypertension (HTN) in young subjects. METHODS: From the Health Examination Registration System of Taiwanese military service during the period 2013-2015, there were 46,561 eligible participants who were 20years old or older in our study. Different analytical steps of analysis were performed to examine the association between UA and cardiometabolic risk using logistic regression, receiver operating characteristic (ROC) curve analysis and Cox regression. RESULTS: For total population, serum UA had significant associations with the presence of MetS (OR=2.08, 95% CI=1.51-2.87), DM (OR=2.59, 95% CI=1.09-6.19) and HTN (OR=1.49, 95% CI=1.07-2.07) in the cross-sectional analysis. According to the cut-off values of UA calculating by the ROC curve analysis in each sex/age subgroup, the association between UA and incident adverse outcomes were analyzed in a longitudinal study. In male, higher UA significantly increased the risks for developing MetS in 30-40years (HR=1.12, 95% CI=1.01-1.25), DM in <30years (HR=2.75, 95% CI=1.38-5.45) and HTN in all subgroups (HR=1.17, 95% CI=1.01-1.37; HR=1.65, 95% CI=1.08-2.53; HR=1.72, 95% CI=1.22-2.43). In females, a higher UA was significantly associated with an increased risk of incident MetS in >40years (HR=2.99, 95% CI=1.34-6.64), HTN in >40years (HR=2.58, 95% CI=1.02-6.55), and no increased risk of DM. CONCLUSIONS: Our study concluded that serum UA is an important predictor for the risk of incident MetS, DM, and HTN in adults, especially in male population.