Xiuhua Shen1,2, Shouling Wu3, Renying Xu4,5, Yuntao Wu6, Junjuan Li7, Liufu Cui8, Rong Shu8, Xiang Gao9. 1. Department of Clinical Nutrition, Shanghai Xin Hua Hospital, Shanghai, China. 2. Department of Nutrition, School of Medicine, Shanghai Jiao Tong University, Shanghai, China. 3. Department of Cardiology, Kailuan General Hospital, No. 57 Xinhua Road (East), Tangshan, 063000, China. drwusl@163.com. 4. Department of Clinical Nutrition, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China. 5. Shanghai Key Laboratory of Pediatric Gastroenterology and Nutrition, Shanghai, China. 6. Department of Cardiology, Kailuan General Hospital, No. 57 Xinhua Road (East), Tangshan, 063000, China. 7. Department of Nephrology, Kailuan General Hospital, Tangshan, China. 8. Department of Rheumatology, Kailuan General Hospital, Tangshan, China. 9. Department of Nutritional Sciences, The Pennsylvania State University, University Park, PA, 16802, USA. xxg14@psu.edu.
Abstract
BACKGROUND/ OBJECTIVE: Neck circumference (NC) is associated with metabolic abnormalities, independent of other obesity indices. However, data are limited regarding the potential relation between NC and serum uric acid (UA) concentrations. Therefore, we evaluated the cross-sectional association between NC and UA concentration, and odds of having hyperuricemia in a community-based cohort. SUBJECTS AND METHODS: The current study included 87,782 participants (16,317 women and 71,465 men, 52.2 ± 14.1 y) of the Kailuan Study. NC and UA concentration were measured in 2014. We used generalized linear model to investigate the association between NC and serum UA concentration and logistic regression model to investigate the association between NC and likelihood of having hyperuricemia (≥ 7 mg/dl in men and ≥ 6 mg/dl in women), adjusting for demographic factor, anthropometric indices, plasma lipid profiles, blood glucose, blood pressure, physical exercise, snoring, smoking, diet quality, and alcohol consumption. RESULTS: Higher NC was associated with higher serum UA concentration, and higher odds of hyperuricemia in both men and women after adjusting for potential confounders (both p < 0.001). Each additional 5-cm increase in NC was associated with 6% higher likelihood of having hyperuricemia (adjusted OR = 1.06; 95% CI 1.02, 1.1) in men and 17% in women (adjusted OR = 1.17; 95% CI 1.06, 1.28) (p interaction = 0.01). Similar pattern was observed after excluding participants who reported use of anti-hypertensive drugs, participants with obesity or higher waist circumference, and participants with history of gout and chronic kidney diseases. CONCLUSIONS: Higher NC was associated with higher serum UA concentration and higher risk of hyperuricemia in Chinese adult population. CLINICAL TRIAL NUMBER: Kailuan Study (ChiCTR-TNRC-11001489).
BACKGROUND/ OBJECTIVE: Neck circumference (NC) is associated with metabolic abnormalities, independent of other obesity indices. However, data are limited regarding the potential relation between NC and serum uric acid (UA) concentrations. Therefore, we evaluated the cross-sectional association between NC and UA concentration, and odds of having hyperuricemia in a community-based cohort. SUBJECTS AND METHODS: The current study included 87,782 participants (16,317 women and 71,465 men, 52.2 ± 14.1 y) of the Kailuan Study. NC and UA concentration were measured in 2014. We used generalized linear model to investigate the association between NC and serum UA concentration and logistic regression model to investigate the association between NC and likelihood of having hyperuricemia (≥ 7 mg/dl in men and ≥ 6 mg/dl in women), adjusting for demographic factor, anthropometric indices, plasma lipid profiles, blood glucose, blood pressure, physical exercise, snoring, smoking, diet quality, and alcohol consumption. RESULTS: Higher NC was associated with higher serum UA concentration, and higher odds of hyperuricemia in both men and women after adjusting for potential confounders (both p < 0.001). Each additional 5-cm increase in NC was associated with 6% higher likelihood of having hyperuricemia (adjusted OR = 1.06; 95% CI 1.02, 1.1) in men and 17% in women (adjusted OR = 1.17; 95% CI 1.06, 1.28) (p interaction = 0.01). Similar pattern was observed after excluding participants who reported use of anti-hypertensive drugs, participants with obesity or higher waist circumference, and participants with history of gout and chronic kidney diseases. CONCLUSIONS: Higher NC was associated with higher serum UA concentration and higher risk of hyperuricemia in Chinese adult population. CLINICAL TRIAL NUMBER: Kailuan Study (ChiCTR-TNRC-11001489).
Authors: Sarah Rosner Preis; Joseph M Massaro; Udo Hoffmann; Ralph B D'Agostino; Daniel Levy; Sander J Robins; James B Meigs; Ramachandran S Vasan; Christopher J O'Donnell; Caroline S Fox Journal: J Clin Endocrinol Metab Date: 2010-05-19 Impact factor: 5.958
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