BACKGROUND: A recent study demonstrated that immune-checkpoint molecules are associated with tumoral immune evasion. MATERIALS AND METHODS: Programmed cell death protein 1 (PD-1) expression on CD4+ and CD8+ T-cells obtained from gastric cancer tissue was evaluated by multicolor flow cytometry. Immunohistochemical staining was also performed to evaluate programmed cell death ligand-1 (PD-L1) expression on gastric cancer cells. RESULTS: There were statistically significant correlations between PD-L1 expression and age, histology, tumor size, depth of invasion, lymph node metastasis, lymphatic vessel invasion, venous invasion, and disease stage. The 5-year survival rates of patients with and without PD-L1-positive tumors were 48.9% and 80.7%, respectively, and the difference was statistically significant. Multivariate analysis indicated that PD-L1 expression was an independent prognostic indicator. The frequency of PD-1-positive CD4+ and CD8+ T-cells from gastric cancer tissue with PD-L1 expression was significantly more than that from gastric cancer tissue without PD-L1 expression. CONCLUSION: PD-L1 expression was related to a poor prognosis in patients with gastric cancer. Furthermore, PD-1 expression on T-cells was up-regulated in patients with tumors with PD-L1 expression. Copyright
BACKGROUND: A recent study demonstrated that immune-checkpoint molecules are associated with tumoral immune evasion. MATERIALS AND METHODS:Programmed cell death protein 1 (PD-1) expression on CD4+ and CD8+ T-cells obtained from gastric cancer tissue was evaluated by multicolor flow cytometry. Immunohistochemical staining was also performed to evaluate programmed cell death ligand-1 (PD-L1) expression on gastric cancer cells. RESULTS: There were statistically significant correlations between PD-L1 expression and age, histology, tumor size, depth of invasion, lymph node metastasis, lymphatic vessel invasion, venous invasion, and disease stage. The 5-year survival rates of patients with and without PD-L1-positive tumors were 48.9% and 80.7%, respectively, and the difference was statistically significant. Multivariate analysis indicated that PD-L1 expression was an independent prognostic indicator. The frequency of PD-1-positive CD4+ and CD8+ T-cells from gastric cancer tissue with PD-L1 expression was significantly more than that from gastric cancer tissue without PD-L1 expression. CONCLUSION:PD-L1 expression was related to a poor prognosis in patients with gastric cancer. Furthermore, PD-1 expression on T-cells was up-regulated in patients with tumors with PD-L1 expression. Copyright
Authors: Rodolfo Daniel Cervantes-Villagrana; Damaris Albores-García; Alberto Rafael Cervantes-Villagrana; Sara Judit García-Acevez Journal: Signal Transduct Target Ther Date: 2020-06-18
Authors: Nghiem Xuan Hoan; Pham Thi Minh Huyen; Mai Thanh Binh; Ngo Tat Trung; Dao Phuong Giang; Bui Thuy Linh; Dang Thi Ngoc Dung; Srinivas Reddy Pallerla; Peter G Kremsner; Thirumalaisamy P Velavan; Mai Hong Bang; Le Huu Song Journal: Sci Rep Date: 2021-04-08 Impact factor: 4.379
Authors: Dong Hyun Kim; Go Eun Bae; Kwang Sun Suh; David Ryuman; Kyu Sang Song; Ju Seok Kim; Sang-Il Lee; Min-Kyung Yeo Journal: In Vivo Date: 2020 Nov-Dec Impact factor: 2.155