Marguerite Tyran1, Nathalie Charrier2, Julien Darreon1, Anne Madroszyk3, Agnes Tallet1, Naji Salem4. 1. Department of Radiation Oncology, Paoli-Calmettes Institute, Marseille, France. 2. Department of Nuclear Medicine, Paoli-Calmettes Institute, Marseille, France. 3. Department of Medical Oncology, Paoli-Calmettes Institute, Marseille, France. 4. Department of Radiation Oncology, Paoli-Calmettes Institute, Marseille, France salemn@ipc.unicancer.fr.
Abstract
BACKGROUND/AIM: Radiological evaluation after stereotactic-body-radiotherapy (SBRT) for non-small-cell lung carcinoma (NSCLC) is often difficult due to lung radiation-induced image modifications on computed tomographic (CT) scan. The aim of this study was to evaluate positron-emission tomography-computed tomography (PET-CT) using fluorodeoxyglucose after SBRT in primary lung cancer. PATIENTS AND METHODS: Eighteen patients with histologically proven NSCLC were treated with SBRT. All had PET-CT evaluations before treatment, at 2 to 3 months and at 1 year post SBRT during the follow-up. RESULTS: Early PET-CT in 12/18 patients who did not experience local failure did not show any progression. No conclusion could be drawn in four cases because early PET-CT was disturbed by inflammatory reaction. Early PET-CT was not predictive of late outcome for two patients, as it showed a significant response followed by disease progression on late evaluation. CONCLUSION: Early PET response appears to correlate with local control at 1 year post SBRT. Copyright
BACKGROUND/AIM: Radiological evaluation after stereotactic-body-radiotherapy (SBRT) for non-small-cell lung carcinoma (NSCLC) is often difficult due to lung radiation-induced image modifications on computed tomographic (CT) scan. The aim of this study was to evaluate positron-emission tomography-computed tomography (PET-CT) using fluorodeoxyglucose after SBRT in primary lung cancer. PATIENTS AND METHODS: Eighteen patients with histologically proven NSCLC were treated with SBRT. All had PET-CT evaluations before treatment, at 2 to 3 months and at 1 year post SBRT during the follow-up. RESULTS: Early PET-CT in 12/18 patients who did not experience local failure did not show any progression. No conclusion could be drawn in four cases because early PET-CT was disturbed by inflammatory reaction. Early PET-CT was not predictive of late outcome for two patients, as it showed a significant response followed by disease progression on late evaluation. CONCLUSION: Early PET response appears to correlate with local control at 1 year post SBRT. Copyright
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