Literature DB >> 29273517

miRNA delivery for skin wound healing.

Zhao Meng1, Dezhong Zhou2, Yongsheng Gao1, Ming Zeng1, Wenxin Wang3.   

Abstract

The wound healing has remained a worldwide challenge as one of significant public health problems. Pathological scars and chronic wounds caused by injury, aging or diabetes lead to impaired tissue repair and regeneration. Due to the unique biological wound environment, the wound healing is a highly complicated process, efficient and targeted treatments are still lacking. Hence, research-driven to discover more efficient therapeutics is a highly urgent demand. Recently, the research results have revealed that microRNA (miRNA) is a promising tool in therapeutic and diagnostic fields because miRNA is an essential regulator in cellular physiology and pathology. Therefore, new technologies for wound healing based on miRNA have been developed and miRNA delivery has become a significant research topic in the field of gene delivery.
Copyright © 2017 Elsevier B.V. All rights reserved.

Entities:  

Keywords:  Cutaneous wound healing; MicroRNA; Non-viral delivery; Scarring

Mesh：

Substances：

Year:  2017        PMID： 29273517     DOI： 10.1016/j.addr.2017.12.011

Source DB:  PubMed          Journal:  Adv Drug Deliv Rev        ISSN： 0169-409X            Impact factor:   15.470


  20 in total

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Review 4.  Functional Implications and Clinical Potential of MicroRNAs in Irritable Bowel Syndrome: A Concise Review.

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Journal:  Dig Dis Sci       Date:  2022-05-04       Impact factor: 3.487

Review 5.  Transdermal delivery for gene therapy.

Authors:  Parbeen Singh; I'jaaz Muhammad; Nicole E Nelson; Khanh T M Tran; Tra Vinikoor; Meysam T Chorsi; Ethan D'Orio; Thanh D Nguyen
Journal:  Drug Deliv Transl Res       Date:  2022-05-10       Impact factor: 5.671

Review 6.  Role of MicroRNA in Proliferation Phase of Wound Healing.

Authors:  Amro M Soliman; Srijit Das; Norzana Abd Ghafar; Seong Lin Teoh
Journal:  Front Genet       Date:  2018-02-14       Impact factor: 4.599

7.  Exosomal miR-135a derived from human amnion mesenchymal stem cells promotes cutaneous wound healing in rats and fibroblast migration by directly inhibiting LATS2 expression.

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Journal:  Stem Cell Res Ther       Date:  2020-02-13       Impact factor: 6.832

8.  Identification of differentially expressed miRNAs associated with thermal injury in epidermal stem cells based on RNA-sequencing.

Authors:  Hao-Tian Rong; De-Wu Liu
Journal:  Exp Ther Med       Date:  2020-01-14       Impact factor: 2.447

9.  Gene-Hydrogel Microenvironment Regulates Extracellular Matrix Metabolism Balance in Nucleus Pulposus.

Authors:  Wei Chen; Hao Chen; Dandan Zheng; Hongbo Zhang; Lianfu Deng; Wenguo Cui; Yuhui Zhang; Hélder A Santos; Hongxing Shen
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10.  Exosomes derived from atorvastatin-pretreated MSC accelerate diabetic wound repair by enhancing angiogenesis via AKT/eNOS pathway.

Authors:  Muyu Yu; Wei Liu; Junxian Li; Junxi Lu; Huijuan Lu; Weiping Jia; Fang Liu
Journal:  Stem Cell Res Ther       Date:  2020-08-12       Impact factor: 6.832
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