Hector M González1, Wassim Tarraf2, Kimystian Harrison3, B Gwen Windham4, Jonathan Tingle5, Alvaro Alonso6, Michael Griswold5, Gerardo Heiss7, David Knopman8, Thomas H Mosley9. 1. Department of Neurosciences and Shiley-Marcos Alzheimer's Disease Research Center, University of California San Diego, San Diego, CA, USA. 2. Institute of Gerontology, Department of Healthcare Sciences, Wayne State University, Detroit, MI, USA. 3. School of Medicine, The University of Mississippi Medical Center, Jackson, MS, USA. 4. Department of Medicine, The University of Mississippi Medical Center, Jackson, MS, USA. 5. Department of Data Science, JD Bower School of Population Health, The University of Mississippi Medical Center, Jackson, MS, USA. 6. Department of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, GA, USA. 7. Department of Epidemiology, University of North Carolina, Chapel Hill, NC, USA. 8. Department of Neurology, Mayo Clinic, Rochester, MN, USA. 9. Department of Medicine, The University of Mississippi Medical Center, Jackson, MS, USA; Memory Impairment and Neurodegenerative Dementia (MIND) Center, The University of Mississippi Medical Center, Jackson, MS, USA. Electronic address: mindcenter@umc.edu.
Abstract
INTRODUCTION: The aim was to examine associations between midlife cardiovascular health (CVH) and 20-year cognitive decline among blacks and whites. METHODS: Midlife CVH metrics (American Heart Association's Life's Simple 7) were calculated and examined in relation to midlife and 20-year change in cognitive function among 13,270 whites and blacks from the Atherosclerosis Risk in Communities Cohort Study. We used linear mixed models to estimate adjusted associations of midlife CVH with midlife cognitive status and change. RESULTS: Higher midlife (Life's Simple 7) scores and individual metrics, particularly blood pressure and glucose, were associated with better midlife cognition and reduced 20-year decline. Midlife CVH 20-year neuroprotection was more pronounced among whites than blacks. DISCUSSION: Better midlife CVH was associated with higher midlife and reduced decline in cognitive function 20 years later. However, the benefits of midlife CVH on cognition were stronger for whites than for blacks. Our findings suggest that improved midlife CVH may promote enduring cognitive health.
INTRODUCTION: The aim was to examine associations between midlife cardiovascular health (CVH) and 20-year cognitive decline among blacks and whites. METHODS: Midlife CVH metrics (American Heart Association's Life's Simple 7) were calculated and examined in relation to midlife and 20-year change in cognitive function among 13,270 whites and blacks from the Atherosclerosis Risk in Communities Cohort Study. We used linear mixed models to estimate adjusted associations of midlife CVH with midlife cognitive status and change. RESULTS: Higher midlife (Life's Simple 7) scores and individual metrics, particularly blood pressure and glucose, were associated with better midlife cognition and reduced 20-year decline. Midlife CVH 20-year neuroprotection was more pronounced among whites than blacks. DISCUSSION: Better midlife CVH was associated with higher midlife and reduced decline in cognitive function 20 years later. However, the benefits of midlife CVH on cognition were stronger for whites than for blacks. Our findings suggest that improved midlife CVH may promote enduring cognitive health.
Authors: Hector M González; Wassim Tarraf; Carlos J Rodríguez; Linda C Gallo; Ralph L Sacco; Gregory A Talavera; Gerardo Heiss; Jorge R Kizer; Rosalba Hernandez; Sonia Davis; Neil Schneiderman; Martha L Daviglus; Robert C Kaplan Journal: Am Heart J Date: 2016-02-19 Impact factor: 4.749
Authors: Pamela L Lutsey; Lindsay G S Bengtson; Naresh M Punjabi; Eyal Shahar; Thomas H Mosley; Rebecca F Gottesman; Lisa M Wruck; Richard F MacLehose; Alvaro Alonso Journal: Sleep Date: 2016-02-01 Impact factor: 5.849
Authors: Rebecca F Gottesman; Andreea M Rawlings; A Richey Sharrett; Marilyn Albert; Alvaro Alonso; Karen Bandeen-Roche; Laura H Coker; Josef Coresh; David J Couper; Michael E Griswold; Gerardo Heiss; David S Knopman; Mehul D Patel; Alan D Penman; Melinda C Power; Ola A Selnes; Andrea L C Schneider; Lynne E Wagenknecht; B Gwen Windham; Lisa M Wruck; Thomas H Mosley Journal: Am J Epidemiol Date: 2014-03-13 Impact factor: 4.897
Authors: Matthew P Pase; Alexa Beiser; Danielle Enserro; Vanessa Xanthakis; Hugo Aparicio; Claudia L Satizabal; Jayandra J Himali; Carlos S Kase; Ramachandran S Vasan; Charles DeCarli; Sudha Seshadri Journal: Stroke Date: 2016-04-12 Impact factor: 7.914
Authors: Ejovwoke R Ogagarue; Pamela L Lutsey; Ronald Klein; Barbara E Klein; Aaron R Folsom Journal: J Am Heart Assoc Date: 2013-11-19 Impact factor: 5.501
Authors: Casey M Rebholz; Cheryl A M Anderson; Morgan E Grams; Lydia A Bazzano; Deidra C Crews; Alex R Chang; Josef Coresh; Lawrence J Appel Journal: J Am Heart Assoc Date: 2016-04-06 Impact factor: 5.501
Authors: Hannah Gardener; Clinton B Wright; Chuanhui Dong; Ken Cheung; Janet DeRosa; Micaela Nannery; Yaakov Stern; Mitchell S V Elkind; Ralph L Sacco Journal: J Am Heart Assoc Date: 2016-03-16 Impact factor: 5.501
Authors: Jaime Perales-Puchalt; Michelle L Vidoni; Juan Llibre Rodríguez; Eric D Vidoni; Sandra Billinger; Jeffrey Burns; Maëlenn Guerchet; MinJae Lee Journal: Int J Geriatr Psychiatry Date: 2019-04-23 Impact factor: 3.485
Authors: Ronald M Lazar; Virginia J Howard; Walter N Kernan; Hugo J Aparicio; Deborah A Levine; Anthony J Viera; Lori C Jordan; David L Nyenhuis; Katherine L Possin; Farzaneh A Sorond; Carole L White Journal: Stroke Date: 2021-03-15 Impact factor: 7.914