INTRODUCTION: Late-life depression (LLD) is common, but remains underdiagnosed. Validated screening tools for use with the oldest-old in clinical practice are still lacking, particularly in developing countries. OBJECTIVES: To evaluate the accuracy of a screening tool for LLD in a community-dwelling oldest-old sample. METHODS: We evaluated 457 community-dwelling elderly subjects, aged ≥75 years and without dementia, with the Geriatric Depression Scale (GDS-15). Depression diagnosis was established according to DSM-IV criteria following a structured psychiatric interview with the Mini International Neuropsychiatric Interview (MINI). RESULTS: Fifty-two individuals (11.4%) were diagnosed with major depression. The area under the receiver operating characteristic (ROC) curve was 0.908 (p<0.001). Using a cut-off score of 5/6 (not depressed/depressed), 84 (18.4%) subjects were considered depressed by the GDS-15 (kappa coefficient = 53.8%, p<0.001). The 4/5 cut-off point achieved the best combination of sensitivity (86.5%) and specificity (82.7%) (Youden's index = 0.692), with robust negative (0.9802) and reasonable positive predictive values (0.3819). CONCLUSION: GDS-15 showed good accuracy as a screening tool for major depression in this community-based sample of low-educated oldest-old individuals. Our findings support the use of the 4/5 cut-off score, which showed the best diagnostic capacity.
INTRODUCTION: Late-life depression (LLD) is common, but remains underdiagnosed. Validated screening tools for use with the oldest-old in clinical practice are still lacking, particularly in developing countries. OBJECTIVES: To evaluate the accuracy of a screening tool for LLD in a community-dwelling oldest-old sample. METHODS: We evaluated 457 community-dwelling elderly subjects, aged ≥75 years and without dementia, with the Geriatric Depression Scale (GDS-15). Depression diagnosis was established according to DSM-IV criteria following a structured psychiatric interview with the Mini International Neuropsychiatric Interview (MINI). RESULTS: Fifty-two individuals (11.4%) were diagnosed with major depression. The area under the receiver operating characteristic (ROC) curve was 0.908 (p<0.001). Using a cut-off score of 5/6 (not depressed/depressed), 84 (18.4%) subjects were considered depressed by the GDS-15 (kappa coefficient = 53.8%, p<0.001). The 4/5 cut-off point achieved the best combination of sensitivity (86.5%) and specificity (82.7%) (Youden's index = 0.692), with robust negative (0.9802) and reasonable positive predictive values (0.3819). CONCLUSION: GDS-15 showed good accuracy as a screening tool for major depression in this community-based sample of low-educated oldest-old individuals. Our findings support the use of the 4/5 cut-off score, which showed the best diagnostic capacity.
Authors: John T Schousboe; Tien N Vo; Allyson M Kats; Lisa Langsetmo; Susan J Diem; Brent C Taylor; Elsa S Strotmeyer; Kristine E Ensrud Journal: J Am Geriatr Soc Date: 2019-03-23 Impact factor: 5.562
Authors: Gregory E Hicks; Ryan T Pohlig; Peter C Coyle; J Megan Sions; Debra K Weiner; Jenifer M Pugliese; Teonette O Velasco; Victoria A O'Brien Journal: Phys Ther Date: 2021-12-01
Authors: Q Wu; R Fu; M F Zhao; Y G Ma; H Jiang; L D Hu; Y Jing; H Liu; L R Wang; L Su; Y Q Zhang; C L Zhou; Y Zhang; H Y Ren; B Jiang; H B Zhou; L Kang; L Zhang; D B Zhou; J Li Journal: Zhonghua Xue Ye Xue Za Zhi Date: 2019-01-14
Authors: Ben Schöttker; Sabine Kuznia; Dana Clarissa Laetsch; David Czock; Annette Kopp-Schneider; Reiner Caspari; Hermann Brenner Journal: BMC Cancer Date: 2020-08-08 Impact factor: 4.430