| Literature DB >> 29263216 |
Lara Campana1,2, Philip J Starkey Lewis2, Antonella Pellicoro3, Rebecca L Aucott3, Janet Man2, Eoghan O'Duibhir2, Sarah E Mok4, Sofia Ferreira-Gonzalez2, Eilidh Livingstone2, Stephen N Greenhalgh3, Katherine L Hull5, Timothy J Kendall3,6, Douglas Vernimmen7, Neil C Henderson3, Luke Boulter8, Christopher D Gregory3, Yi Feng3, Stephen M Anderton3, Stuart J Forbes3,2, John P Iredale3,9.
Abstract
The disposal of apoptotic bodies by professional phagocytes is crucial to effective inflammation resolution. Our ability to improve the disposal of apoptotic bodies by professional phagocytes is impaired by a limited understanding of the molecular mechanisms that regulate the engulfment and digestion of the efferocytic cargo. Macrophages are professional phagocytes necessary for liver inflammation, fibrosis, and resolution, switching their phenotype from proinflammatory to restorative. Using sterile liver injury models, we show that the STAT3-IL-10-IL-6 axis is a positive regulator of macrophage efferocytosis, survival, and phenotypic conversion, directly linking debris engulfment to tissue repair.Entities:
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Year: 2017 PMID： 29263216 PMCID： PMC5784823 DOI： 10.4049/jimmunol.1701247
Source DB: PubMed Journal: J Immunol ISSN： 0022-1767 Impact factor: 5.422