Zhe Fan1, Yingyi Zhang1, Jiyong Pan1, Shuang Wang2. 1. Department of General Surgery, the Third People's Hospital of Dalian, Dalian Medical University, Dalian, China. 2. Graduate School, Dalian Medical University, Dalian, China wangshuang1986721@163.com.
Abstract
BACKGROUND: Acute appendicitis (AA) is a common condition in general surgery, often with serious consequences such as septicemia and intra-abdominal infection. Mean platelet volume (MPV) - a platelet parameter - could be an index of inflammation. We carried out the present study to perform a meta-analysis of AA and MPV. METHODS: A systematic search was conducted in databases of PubMed and Embase from 1966 to 2015. Weighted mean difference and 95% confidence interval (CI) were then calculated. Finally, statistical analysis was carried out using Stata 12.0 software. RESULTS: Of the 88 selected studies, five case-control studies met the selection criteria. These cases, comprised1416 cases of AA and 685 controls. The results showed a prominent decrease of MPV levels in patients suffering from AA, compared to the control group. (weighted mean difference, -0.64; 95% CI, -0.74 to -0.54; P=0.037). CONCLUSIONS: AA cases had a lower MPV than the controls, which supports MPV as a potential biomarker of AA.
BACKGROUND: Acute appendicitis (AA) is a common condition in general surgery, often with serious consequences such as septicemia and intra-abdominal infection. Mean platelet volume (MPV) - a platelet parameter - could be an index of inflammation. We carried out the present study to perform a meta-analysis of AA and MPV. METHODS: A systematic search was conducted in databases of PubMed and Embase from 1966 to 2015. Weighted mean difference and 95% confidence interval (CI) were then calculated. Finally, statistical analysis was carried out using Stata 12.0 software. RESULTS: Of the 88 selected studies, five case-control studies met the selection criteria. These cases, comprised1416 cases of AA and 685 controls. The results showed a prominent decrease of MPV levels in patients suffering from AA, compared to the control group. (weighted mean difference, -0.64; 95% CI, -0.74 to -0.54; P=0.037). CONCLUSIONS: AA cases had a lower MPV than the controls, which supports MPV as a potential biomarker of AA.
Authors: M Murat Oktay; Mustafa Boğan; Selcan Türker Çolak; Mustafa Sabak; Hasan Gümüşboğa; Sevki Hakan Eren Journal: J Int Med Res Date: 2020-09 Impact factor: 1.671