| Literature DB >> 29255284 |
Paul I Costea1, Falk Hildebrand1,2,3, Manimozhiyan Arumugam4, Fredrik Bäckhed5,6, Martin J Blaser7, Frederic D Bushman8, Willem M de Vos9,10, S Dusko Ehrlich11,12, Claire M Fraser13, Masahira Hattori14, Curtis Huttenhower15, Ian B Jeffery16, Dan Knights17,18, James D Lewis19, Ruth E Ley20, Howard Ochman21, Paul W O'Toole16, Christopher Quince22, David A Relman23,24,25, Fergus Shanahan16, Shinichi Sunagawa1,26, Jun Wang5,27,28,29,30, George M Weinstock31, Gary D Wu32, Georg Zeller1, Liping Zhao33, Jeroen Raes34,35,36, Rob Knight37,38,39,40, Peer Bork41,42,43.
Abstract
Population stratification is a useful approach for a better understanding of complex biological problems in human health and wellbeing. The proposal that such stratification applies to the human gut microbiome, in the form of distinct community composition types termed enterotypes, has been met with both excitement and controversy. In view of accumulated data and re-analyses since the original work, we revisit the concept of enterotypes, discuss different methods of dividing up the landscape of possible microbiome configurations, and put these concepts into functional, ecological and medical contexts. As enterotypes are of use in describing the gut microbial community landscape and may become relevant in clinical practice, we aim to reconcile differing views and encourage a balanced application of the concept.Entities:
Mesh：
Substances：
Year: 2017 PMID： 29255284 PMCID： PMC5832044 DOI： 10.1038/s41564-017-0072-8
Source DB: PubMed Journal: Nat Microbiol ISSN： 2058-5276 Impact factor: 17.745