Literature DB >> 2924769

Solution conformation of sialosylcerebroside (GM4) and its NeuAc(alpha 2----3)Gal beta sugar component.

L Poppe1, J Dabrowski, C W von der Lieth, M Numata, T Ogawa.   

Abstract

The solution conformations of GM4 ganglioside [NeuAc(alpha 2----3)Gal (beta 1----1)Cer] in (2H3C)2SO and its component disaccharide in 2H2O were investigated with the aid of 1H-nuclear magnetic resonance spectroscopy (nuclear Overhauser effect, analysis of coupling constants) and by energy-minimum calculations. The existence of three low-energy conformers obtained by theoretical calculations was supported by experimental findings in the case of GM4, whereas the disaccharide appears to exist as a mixture of two conformers.

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Year:  1989        PMID： 2924769     DOI： 10.1111/j.1432-1033.1989.tb14653.x

Source DB:  PubMed          Journal:  Eur J Biochem        ISSN： 0014-2956


  10 in total

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  10 in total

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