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Literature DB >> 12374188

Mimicking gangliosides by design: mimics of GM1 headgroup.

Anna Bernardi¹, Daniela Arosio, Sandro Sonnino.

Abstract

Detailed knowledge of the three-dimensional structure of ganglioside headgroups has allowed the successful design of structural and functional mimics of ganglioside GMI oligosaccharide. Our recent work in this area is reviewed in this paper.

Entities: Chemical

Mesh：

Substances：
G(M1) Ganglioside

Year: 2002 PMID： 12374188 DOI： 10.1023/a:1020251428217

Source DB: PubMed Journal: Neurochem Res ISSN： 0364-3190 Impact factor: 3.996

27 in total

Review 1. AB5 toxins.

Authors: E A Merritt; W G Hol
Journal: Curr Opin Struct Biol Date: 1995-04 Impact factor: 6.809

Review 2. Animal glycosphingolipids as membrane attachment sites for bacteria.

Authors: K A Karlsson
Journal: Annu Rev Biochem Date: 1989 Impact factor: 23.643

Review 3. Bifunctional role of glycosphingolipids. Modulators for transmembrane signaling and mediators for cellular interactions.

Authors: S Hakomori
Journal: J Biol Chem Date: 1990-11-05 Impact factor: 5.157

4. Structure and dynamics of the sialic acid moiety of GM3-ganglioside at the surface of a magnetically oriented membrane.

Authors: Y Aubin; Y Ito; J C Paulson; J H Prestegard
Journal: Biochemistry Date: 1993-12-14 Impact factor: 3.162

5. Solution conformation of sialosylcerebroside (GM4) and its NeuAc(alpha 2----3)Gal beta sugar component.

Authors: L Poppe; J Dabrowski; C W von der Lieth; M Numata; T Ogawa
Journal: Eur J Biochem Date: 1989-03-15

6. Second-generation mimics of ganglioside GM1 oligosaccharide: a three-dimensional view of their interactions with bacterial enterotoxins by NMR and computational methods.

Authors: Anna Bernardi; Donatella Potenza; Anna Maria Capelli; Alicia García-Herrero; F Javier Cañada; Jesús Jiménez-Barbero
Journal: Chemistry Date: 2002-10-18 Impact factor: 5.236

Mimicking gangliosides by design: mimics of GM1 headgroup.

Review 1. AB5 toxins.

Review 2. Animal glycosphingolipids as membrane attachment sites for bacteria.

Review 3. Bifunctional role of glycosphingolipids. Modulators for transmembrane signaling and mediators for cellular interactions.

4. Structure and dynamics of the sialic acid moiety of GM3-ganglioside at the surface of a magnetically oriented membrane.

5. Solution conformation of sialosylcerebroside (GM4) and its NeuAc(alpha 2----3)Gal beta sugar component.

6. Second-generation mimics of ganglioside GM1 oligosaccharide: a three-dimensional view of their interactions with bacterial enterotoxins by NMR and computational methods.

7. Molecular dynamics simulation of oligosaccharides containing N-acetyl neuraminic acid.

8. Carbohydrate dynamics at a micellar surface: GD1a headgroup transformations revealed by NMR spectroscopy.

9. Crystal structure of cholera toxin B-pentamer bound to receptor GM1 pentasaccharide.

Review 10. Structure and function of cholera toxin and the related Escherichia coli heat-labile enterotoxin.

Review 1. Carbohydrate inhibitors of cholera toxin.