Yelena P Wu1,2, Wendy Kohlmann3, Karen Curtin3,4, Zhe Yu3, Heidi A Hanson3,5, Mia Hashibe3,6, Bridget G Parsons3, Jathine Wong3, Joshua D Schiffman3,7, Douglas Grossman3,8, Sancy A Leachman9. 1. Huntsman Cancer Institute, University of Utah, Salt Lake City, UT, USA. yelena.wu@utah.edu. 2. Departments of Dermatology and Oncological Sciences, University of Utah, Salt Lake City, UT, USA. yelena.wu@utah.edu. 3. Huntsman Cancer Institute, University of Utah, Salt Lake City, UT, USA. 4. Department of Medicine, University of Utah, Salt Lake City, UT, USA. 5. Department of Surgery, University of Utah, Salt Lake City, UT, USA. 6. Division of Public Health, Department of Family and Preventive Medicine, University of Utah, Salt Lake City, UT, USA. 7. Department of Pediatrics, University of Utah, Salt Lake City, UT, USA. 8. Departments of Dermatology and Oncological Sciences, University of Utah, Salt Lake City, UT, USA. 9. Department of Dermatology, Oregon Health and Science University, Portland, OR, USA.
Abstract
PURPOSE: The aim of this study was to determine risk for melanoma among individuals who have a first- or second-degree relative with a history of melanoma, based on the unaffected individual's age and age at diagnosis of the relative. METHODS: The study employed a case-control design using a statewide database linked with a Surveillance Epidemiology and End Results cancer registry. A population-based sample of individuals who received at least one diagnosis of first primary, malignant melanoma (n = 14,281), as well as their first- and second-degree relatives, was included. Control individuals with no history of melanoma (n = 70,889) were matched to cases on birth year, gender, race/ethnicity, and county at birth. RESULTS: Risk for melanoma among relatives of melanoma patients declined with relative's age and age at diagnosis. Individuals between ages 40 and 49 who are first-degree relatives of melanoma patients diagnosed between ages 40 and 49 had the greatest risk for melanoma compared with individuals without a first-degree relative with a melanoma history (HR 4.89; 95% CI 3.11-7.68). Increased melanoma risk among second-degree relatives of patients was typically lower than that for first-degree relatives. CONCLUSIONS: Risk for melanoma, at earlier ages than expected, is increased among relatives of individuals with a history of melanoma, particularly if the melanoma case was diagnosed at a young age. Further research on the relationship between age at diagnosis and relative's melanoma risk could inform melanoma screening recommendations for individuals with a family history of the disease.
PURPOSE: The aim of this study was to determine risk for melanoma among individuals who have a first- or second-degree relative with a history of melanoma, based on the unaffected individual's age and age at diagnosis of the relative. METHODS: The study employed a case-control design using a statewide database linked with a Surveillance Epidemiology and End Results cancer registry. A population-based sample of individuals who received at least one diagnosis of first primary, malignant melanoma (n = 14,281), as well as their first- and second-degree relatives, was included. Control individuals with no history of melanoma (n = 70,889) were matched to cases on birth year, gender, race/ethnicity, and county at birth. RESULTS: Risk for melanoma among relatives of melanomapatients declined with relative's age and age at diagnosis. Individuals between ages 40 and 49 who are first-degree relatives of melanomapatients diagnosed between ages 40 and 49 had the greatest risk for melanoma compared with individuals without a first-degree relative with a melanoma history (HR 4.89; 95% CI 3.11-7.68). Increased melanoma risk among second-degree relatives of patients was typically lower than that for first-degree relatives. CONCLUSIONS: Risk for melanoma, at earlier ages than expected, is increased among relatives of individuals with a history of melanoma, particularly if the melanoma case was diagnosed at a young age. Further research on the relationship between age at diagnosis and relative's melanoma risk could inform melanoma screening recommendations for individuals with a family history of the disease.
Entities:
Keywords:
Age at diagnosis; Early detection; Familial risk; Melanoma
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