BACKGROUND: Previous studies find that both schizophrenia and mood disorder risk alleles contribute to adult depression and anxiety. Emotional problems (depression or anxiety) begin in childhood and show strong continuities into adult life; this suggests that symptoms are the manifestation of the same underlying liability across different ages. However, other findings suggest that there are developmental differences in the etiology of emotional problems at different ages. To our knowledge, no study has prospectively examined the impact of psychiatric risk alleles on emotional problems at different ages in the same individuals. METHODS: Data were analyzed using regression-based analyses in a prospective, population-based UK cohort (the National Child Development Study). Schizophrenia and major depressive disorder (MDD) polygenic risk scores (PRS) were derived from published Psychiatric Genomics Consortium genome-wide association studies. Emotional problems were assessed prospectively at six time points from age 7 to 42 years. RESULTS: Schizophrenia PRS were associated with emotional problems from childhood [age 7, OR 1.09 (1.03-1.15), p = 0.003] to mid-life [age 42, OR 1.10 (1.05-1.17), p < 0.001], while MDD PRS were associated with emotional problems only in adulthood [age 42, OR 1.06 (1.00-1.11), p = 0.034; age 7, OR 1.03 (0.98-1.09), p = 0.228]. CONCLUSIONS: Our prospective investigation suggests that early (childhood) emotional problems in the general population share genetic risk with schizophrenia, while later (adult) emotional problems also share genetic risk with MDD. The results suggest that the genetic architecture of depression/anxiety is not static across development.
BACKGROUND: Previous studies find that both schizophrenia and mood disorder risk alleles contribute to adult depression and anxiety. Emotional problems (depression or anxiety) begin in childhood and show strong continuities into adult life; this suggests that symptoms are the manifestation of the same underlying liability across different ages. However, other findings suggest that there are developmental differences in the etiology of emotional problems at different ages. To our knowledge, no study has prospectively examined the impact of psychiatric risk alleles on emotional problems at different ages in the same individuals. METHODS: Data were analyzed using regression-based analyses in a prospective, population-based UK cohort (the National Child Development Study). Schizophrenia and major depressive disorder (MDD) polygenic risk scores (PRS) were derived from published Psychiatric Genomics Consortium genome-wide association studies. Emotional problems were assessed prospectively at six time points from age 7 to 42 years. RESULTS:Schizophrenia PRS were associated with emotional problems from childhood [age 7, OR 1.09 (1.03-1.15), p = 0.003] to mid-life [age 42, OR 1.10 (1.05-1.17), p < 0.001], while MDD PRS were associated with emotional problems only in adulthood [age 42, OR 1.06 (1.00-1.11), p = 0.034; age 7, OR 1.03 (0.98-1.09), p = 0.228]. CONCLUSIONS: Our prospective investigation suggests that early (childhood) emotional problems in the general population share genetic risk with schizophrenia, while later (adult) emotional problems also share genetic risk with MDD. The results suggest that the genetic architecture of depression/anxiety is not static across development.
Authors: Camilla Jerlang Christiani; Jens R M Jepsen; Anne Thorup; Nicoline Hemager; Ditte Ellersgaard; Katrine S Spang; Birgitte K Burton; Maja Gregersen; Anne Søndergaard; Aja N Greve; Ditte L Gantriis; Gry Poulsen; Md Jamal Uddin; Larry J Seidman; Ole Mors; Kerstin J Plessen; Merete Nordentoft Journal: Schizophr Bull Date: 2019-10-24 Impact factor: 9.306
Authors: Lucy Riglin; Gemma Hammerton; Jon Heron; Stephan Collishaw; Louise Arseneault; Ajay K Thapar; Barbara Maughan; Michael C O'Donovan; Anita Thapar Journal: Am J Psychiatry Date: 2018-11-29 Impact factor: 18.112
Authors: Lucy Riglin; Ajay K Thapar; Beate Leppert; Joanna Martin; Alexander Richards; Richard Anney; George Davey Smith; Kate Tilling; Evie Stergiakouli; Benjamin B Lahey; Michael C O'Donovan; Stephan Collishaw; Anita Thapar Journal: Behav Genet Date: 2019-12-11 Impact factor: 2.805
Authors: Wonuola A Akingbuwa; Anke R Hammerschlag; Eshim S Jami; Andrea G Allegrini; Ville Karhunen; Hannah Sallis; Helga Ask; Ragna B Askeland; Bart Baselmans; Elizabeth Diemer; Fiona A Hagenbeek; Alexandra Havdahl; Jouke-Jan Hottenga; Hamdi Mbarek; Fernando Rivadeneira; Martin Tesli; Catharina van Beijsterveldt; Gerome Breen; Cathryn M Lewis; Anita Thapar; Dorret I Boomsma; Ralf Kuja-Halkola; Ted Reichborn-Kjennerud; Per Magnus; Kaili Rimfeld; Eivind Ystrom; Marjo-Riitta Jarvelin; Paul Lichtenstein; Sebastian Lundstrom; Marcus R Munafò; Robert Plomin; Henning Tiemeier; Michel G Nivard; Meike Bartels; Christel M Middeldorp Journal: JAMA Psychiatry Date: 2020-07-01 Impact factor: 21.596