Jinzhen Song1, Jianbo Huang2, He Huang1, Shiyu Liu3, Yan Luo4. 1. Department of Ultrasound, West China Hospital, Sichuan University, No. 37 Guo Xue Xiang, 610041 Chengdu, Sichuan Province, PR China. 2. Laboratory of Clinical Ultrasound Imaging Drug, West China Hospital of Sichuan University, Chengdu, China. 3. Department of Obstetrics and Gynecology, West China Second Hospital, Sichuan University, 610041 Chengdu, Sichuan Province, PR China. 4. Department of Ultrasound, West China Hospital, Sichuan University, No. 37 Guo Xue Xiang, 610041 Chengdu, Sichuan Province, PR China. Electronic address: wchluoyan@163.com.
Abstract
AIM: Our purpose was to evaluate the correlation between spleen stiffness (SS) measured by ultrasound-based elastography and hepatic venous pressure gradient (HVPG) and assess the accuracy of SS in detecting clinical significant portal hypertension (CSPH) and severe portal hypertension. METHOD: Nine studies were included from thorough literature research and selection processes. A random model was used to analyze the correlation between HVPG and SS. We adopted the bivariate mixed effects model to assess the diagnostic performance. RESULTS: Regarding to correlation between SS and HVPG, the summary correlation coefficient was 0.72 (95% confidence interval [CI], 0.63-0.80). In detection of CSPH, the sensitivity, specificity, AUC and DOR were: 0.88 (0.70-0.96), 0.84 (0.72-0.92), 0.92 (0.89-0.94) and 38 (17-84) for CSPH, respectively; and 0.92 (0.82-0.96), 0.79 (0.72-0.85), 0.87 (0.84-0.90) and 41 (17-100) for severe portal hypertension, respectively. CONCLUSION: Correlation between SS and HVPG was good. Although SS showed good sensitivity and specificity, the different cut-off values and techniques among studies might limit the impact of our results on clinical practice. Therefore, more high-quality prospective studies are required to evaluate the role of SS in predicting portal hypertension.
AIM: Our purpose was to evaluate the correlation between spleen stiffness (SS) measured by ultrasound-based elastography and hepatic venous pressure gradient (HVPG) and assess the accuracy of SS in detecting clinical significant portal hypertension (CSPH) and severe portal hypertension. METHOD: Nine studies were included from thorough literature research and selection processes. A random model was used to analyze the correlation between HVPG and SS. We adopted the bivariate mixed effects model to assess the diagnostic performance. RESULTS: Regarding to correlation between SS and HVPG, the summary correlation coefficient was 0.72 (95% confidence interval [CI], 0.63-0.80). In detection of CSPH, the sensitivity, specificity, AUC and DOR were: 0.88 (0.70-0.96), 0.84 (0.72-0.92), 0.92 (0.89-0.94) and 38 (17-84) for CSPH, respectively; and 0.92 (0.82-0.96), 0.79 (0.72-0.85), 0.87 (0.84-0.90) and 41 (17-100) for severe portal hypertension, respectively. CONCLUSION: Correlation between SS and HVPG was good. Although SS showed good sensitivity and specificity, the different cut-off values and techniques among studies might limit the impact of our results on clinical practice. Therefore, more high-quality prospective studies are required to evaluate the role of SS in predicting portal hypertension.
Authors: Elba Llop; Christie Perelló; Teresa Fontanilla; Juan de la Revilla; Marta Hernández Conde; Marta López; Javier Minaya; Carlos Ferre; Javier Abad; Carlos Fernández Carrillo; José Luís Martínez; Natalia Fernández Puga; María Trapero; Ismael El Hajra; Elena Santos; José Luis Calleja Journal: Front Med (Lausanne) Date: 2022-06-22