Makoto Motoishi1, Satoru Sawai2, Tetsuo Hori3, Naoki Yamashita3. 1. Department of Thoracic Surgery, Mitsubishikyoto Hospital, 1 Katsuragosyo-cho, Nishikyo-ku, Kyoto, 615-8087, Japan. mamotoishi@yahoo.co.jp. 2. Department of Thoracic Surgery, National Hospital Organization Kyoto Medical Center, Fukakusamukaihata-cho, Fushimi-ku, Kyoto, 612-8555, Japan. 3. Department of Thoracic Surgery, Mitsubishikyoto Hospital, 1 Katsuragosyo-cho, Nishikyo-ku, Kyoto, 615-8087, Japan.
Abstract
PURPOSE: The aim of this study was to investigate the influence of a history of diabetes mellitus (DM) and the glycated hemoglobin (HbA1c) level on the survival in patients who underwent complete resection for non-small cell lung cancer (NSCLC). METHODS: Of the patients who underwent complete resection for NSCLC between 2007 and 2015, 468 were classified into DM (who were currently taking medication for DM) and no DM groups as well as into high HbA1c (≥ 6.5) and normal HbA1c (< 6.5) groups. RESULTS: The overall survival (OS) did not differ significantly between either pair of groups. Among the elderly patients, the OS did not differ significantly between the DM and no DM groups, but was significantly higher in the normal-HbA1c group than in the high-HbA1c group (5-year survival rate: 84.7 versus 37.2%, respectively, p < 0.01). In the elderly patients, non-adenocarcinoma histology, advanced stage, a high Charlson comorbidity index, and a high preoperative HbA1c level were found to be independent risk factors for the OS. CONCLUSION: We revealed that a high preoperative HbA1c level was associated with a poor OS in elderly patients who underwent complete resection for NSCLC. This suggests that it is necessary to achieve diabetic control prior to complete resection in NSCLC patients.
PURPOSE: The aim of this study was to investigate the influence of a history of diabetes mellitus (DM) and the glycated hemoglobin (HbA1c) level on the survival in patients who underwent complete resection for non-small cell lung cancer (NSCLC). METHODS: Of the patients who underwent complete resection for NSCLC between 2007 and 2015, 468 were classified into DM (who were currently taking medication for DM) and no DM groups as well as into high HbA1c (≥ 6.5) and normal HbA1c (< 6.5) groups. RESULTS: The overall survival (OS) did not differ significantly between either pair of groups. Among the elderly patients, the OS did not differ significantly between the DM and no DM groups, but was significantly higher in the normal-HbA1c group than in the high-HbA1c group (5-year survival rate: 84.7 versus 37.2%, respectively, p < 0.01). In the elderly patients, non-adenocarcinoma histology, advanced stage, a high Charlson comorbidity index, and a high preoperative HbA1c level were found to be independent risk factors for the OS. CONCLUSION: We revealed that a high preoperative HbA1c level was associated with a poor OS in elderly patients who underwent complete resection for NSCLC. This suggests that it is necessary to achieve diabetic control prior to complete resection in NSCLCpatients.
Authors: M Gryko; J Kiśluk; D Cepowicz; J Zińczuk; Z Kamocki; K Guzińska-Ustymowicz; A Pryczynicz; J Czyżewska; A Kemona; B Kędra Journal: Pol J Pathol Date: 2014-06 Impact factor: 1.072
Authors: Jin-Soo Kim; Edward S Kim; Diane Liu; J Jack Lee; Luisa Solis; Carmen Behrens; Scott M Lippman; Waun Ki Hong; Ignacio I Wistuba; Ho-Young Lee Journal: Clin Lung Cancer Date: 2014-01-01 Impact factor: 4.785
Authors: Goodarz Danaei; Mariel M Finucane; Yuan Lu; Gitanjali M Singh; Melanie J Cowan; Christopher J Paciorek; John K Lin; Farshad Farzadfar; Young-Ho Khang; Gretchen A Stevens; Mayuree Rao; Mohammed K Ali; Leanne M Riley; Carolyn A Robinson; Majid Ezzati Journal: Lancet Date: 2011-06-24 Impact factor: 79.321