Literature DB >> 29221849

Molecular Regulation of Fatty Acid Oxidation in Skeletal Muscle during Aerobic Exercise.

Anne-Marie Lundsgaard1, Andreas Mæchel Fritzen1, Bente Kiens2.   

Abstract

This review summarizes how fatty acid (FA) oxidation is regulated in skeletal muscle during exercise. From the available evidence it seems that acetyl-CoA availability in the mitochondrial matrix adjusts FA oxidation to exercise intensity and duration. This is executed at the step of mitochondrial fatty acyl import, as the extent of acetyl group sequestration by carnitine determines the availability of carnitine for the carnitine palmitoyltransferase 1 (CPT1) reaction. The rate of glycolysis seems therefore to be central to the amount of β-oxidation-derived acetyl-CoA that is oxidized in the tricarboxylic acid (TCA) cycle. FA oxidation during exercise is also determined by FA availability to mitochondria, dependent on trans-sarcolemmal FA uptake via cluster of differentiation 36/SR-B2 (CD36) and FAs mobilized from myocellular lipid droplets.
Copyright © 2017 Elsevier Ltd. All rights reserved.

Entities:  

Keywords:  acetyl-CoA; carnitine; carnitine acyltransferase; carnitine palmitoyltransferase 1; glycolysis; pyruvate dehydrogenase

Mesh：

Substances：

Year:  2017        PMID： 29221849     DOI： 10.1016/j.tem.2017.10.011

Source DB:  PubMed          Journal:  Trends Endocrinol Metab        ISSN： 1043-2760            Impact factor:   12.015


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