Literature DB >> 29217848

A Radio Frequency Radiation Exposure System for Rodents based on Reverberation Chambers.

Myles Capstick1, Niels Kuster2, Sven Kuehn1, Veronica Berdinas-Torres1, Yijian Gong1, Perry Wilson3, John Ladbury3, Galen Koepke3, David L McCormick4, James Gauger4, Ronald L Melnick5.   

Abstract

In this paper we present the novel design features, their technical implementation, and an evaluation of the radio Frequency (RF) exposure systems developed for the National Toxicology Program (NTP) of the National Institute of Environmental Health Sciences (NIEHS) studies on the potential toxicity and carcinogenicity of 2nd and 3rd generation mobile-phone signals. The system requirements for this 2-year NTP cancer bioassay study were the tightly-controlled lifetime exposure of rodents (1568 rats and 1512 mice) to three power levels plus sham simulating typical daily, and higher, exposures of users of GSM and CDMA (IS95) signals. Reverberation chambers and animal housing were designed to allow extended exposure time per day for free-roaming individually-housed animals. The performance of the chamber was characterized in terms of homogeneity, stirred to unstirred energy, efficiency. The achieved homogeneity was 0.59 dB and 0.48 dB at 900 and 1900 MHz respectively. The temporal variation in the electric field strength was optimized to give similar characteristics to that of the power control of a phone in a real network using the two stirrers. Experimental dosimetry was performed to validate the SAR sensitivity and determine the SAR uniformity throughout the exposure volume; SAR uniformities of 0.46 dB and 0.40 dB, respectively, for rats and mice were achieved.

Entities:  

Keywords:  National Toxicology Program; RF exposure; Specific Absorption Rate (SAR); dosimetry; reverberation chambers

Year:  2017        PMID: 29217848      PMCID: PMC5714549          DOI: 10.1109/TEMC.2017.2649885

Source DB:  PubMed          Journal:  IEEE Trans Electromagn Compat        ISSN: 0018-9375            Impact factor:   2.006


  7 in total

1.  Response, thermal regulatory threshold and thermal breakdown threshold of restrained RF-exposed mice at 905 MHz.

Authors:  S Ebert; S J Eom; J Schuderer; U Apostel; T Tillmann; C Dasenbrock; N Kuster
Journal:  Phys Med Biol       Date:  2005-10-19       Impact factor: 3.609

2.  Development of novel whole-body exposure setups for rats providing high efficiency, National Toxicology Program (NTP) compatibility and well-characterized exposure.

Authors:  Wolfgang Kainz; Neviana Nikoloski; Walter Oesch; Veronica Berdiñas-Torres; Jürg Fröhlich; Georg Neubauer; Niels Kuster
Journal:  Phys Med Biol       Date:  2006-09-27       Impact factor: 3.609

3.  Spontaneous and nitrosourea-induced primary tumors of the central nervous system in Fischer 344 rats chronically exposed to 836 MHz modulated microwaves.

Authors:  W R Adey; C V Byus; C D Cain; R J Higgins; R A Jones; C J Kean; N Kuster; A MacMurray; R B Stagg; G Zimmerman; J L Phillips; W Haggren
Journal:  Radiat Res       Date:  1999-09       Impact factor: 2.841

4.  Lymphomas in E mu-Pim1 transgenic mice exposed to pulsed 900 MHZ electromagnetic fields.

Authors:  M H Repacholi; A Basten; V Gebski; D Noonan; J Finnie; A W Harris
Journal:  Radiat Res       Date:  1997-05       Impact factor: 2.841

5.  Life-Time Dosimetric Assessment for Mice and Rats Exposed in Reverberation Chambers of the 2-Year NTP Cancer Bioassay Study on Cell Phone Radiation.

Authors:  Yijian Gong; Myles Capstick; Sven Kuehn; Perry Wilson; John Ladbury; Galen Koepke; David L McCormick; Ronald L Melnick; Niels Kuster
Journal:  IEEE Trans Electromagn Compat       Date:  2017-03-17       Impact factor: 2.006

6.  The effect of chronic exposure to 835.62 MHz FDMA or 847.74 MHz CDMA radiofrequency radiation on the incidence of spontaneous tumors in rats.

Authors:  Marie La Regina; Eduardo G Moros; William F Pickard; William L Straube; Jack Baty; Joseph L Roti Roti
Journal:  Radiat Res       Date:  2003-08       Impact factor: 2.841

7.  The National Toxicology Program rodent bioassay: designs, interpretations, and scientific contributions.

Authors:  John R Bucher
Journal:  Ann N Y Acad Sci       Date:  2002-12       Impact factor: 5.691

  7 in total
  3 in total

1.  Evaluation of the genotoxicity of cell phone radiofrequency radiation in male and female rats and mice following subchronic exposure.

Authors:  Stephanie L Smith-Roe; Michael E Wyde; Matthew D Stout; John W Winters; Cheryl A Hobbs; Kim G Shepard; Amanda S Green; Grace E Kissling; Keith R Shockley; Raymond R Tice; John R Bucher; Kristine L Witt
Journal:  Environ Mol Mutagen       Date:  2019-11-13       Impact factor: 3.216

2.  An International Collaborative Animal Study of the Carcinogenicity of Mobile Phone Radiofrequency Radiation: Considerations for Preparation of a Global Project.

Authors:  Young Hwan Ahn; Katsumi Imaida; Yong-Bum Kim; Kang-Hyun Han; Jeong-Ki Pack; Nam Kim; Sang Bong Jeon; Ae-Kyoung Lee; Hyung Do Choi; Jianqing Wang; Mayumi Kawabe; Hye Sun Kim
Journal:  Bioelectromagnetics       Date:  2022-04-27       Impact factor: 1.848

3.  Thermoregulatory Stress as Potential Mediating Factor in the NTP Cell Phone Tumor Study.

Authors:  Jens Kuhne; Janine-Alison Schmidt; Dirk Geschwentner; Blanka Pophof; Gunde Ziegelberger
Journal:  Bioelectromagnetics       Date:  2020-07-21       Impact factor: 2.010

  3 in total

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