Wei Mao1, Jianjun Zhou2, Mengsu Zeng1, Yuqin Ding1, Lijie Qu1, Caizhong Chen3, Xiaoqiang Ding4, Yaqiong Wang5, Caixia Fu6, Feng Gu7. 1. Department of Radiology, Zhongshan Hospital, Fudan University, Shanghai Institute of Medical Imaging, Shanghai 200032, People's Republic of China. 2. Department of Radiology, Zhongshan Hospital, Fudan University, Shanghai Institute of Medical Imaging, Shanghai 200032, People's Republic of China. Electronic address: zhoujianjunzs@126.com. 3. Department of Radiology, Zhongshan Hospital, Fudan University, Shanghai Institute of Medical Imaging, Shanghai 200032, People's Republic of China. Electronic address: chen.caizhong@zs-hospital.sh.cn. 4. Department of Nephrology, Zhongshan Hospital, Fudan University, Shanghai 200032, People's Republic of China. Electronic address: ding.xiaoqiang@zs-hospital.sh.cn. 5. Department of Nephrology, Zhongshan Hospital, Fudan University, Shanghai 200032, People's Republic of China. Electronic address: wang.yaqiong@zs-hospital.sh.cn. 6. Siemens Shenzhen Magnetic Resonance Ltd., Shenzhen 518057, People's Republic of China. Electronic address: caixia.fu@siemens.com. 7. Department of Radiology, Nantong Second People's Hospital, Nantong 226000, People's Republic of China. Electronic address: gufengjsnt@126.com.
Abstract
PURPOSE: To investigate the potential of Intravoxel incoherent motion diffusion-weighted imaging(IVIM-DWI) for the assessment of renal fibrosis in chronic kidney disease (CKD), using histopathology as a reference standard. METHODS: Eighty-five CKD patients and twenty healthy volunteers were recruited in this study. IVIM-DWI was performed in all of the participants, and all of the CKD patients underwent renal biopsy. The mean values of the true diffusion coefficient (D), pseudo diffusion coefficient (D*) and perfusion fraction (f) in the renal cortex and medulla were compared between the CKD patients and healthy volunteers. The Spearman correlation coefficient was calculated to assess the relationship between the D, D*,f values and the estimated glomerular filtration rate (eGFR), serum creatinine level (SCr), 24h urinary protein level (24h-UPRO), histopathological fibrosis scores. RESULTS: The D, D* and f values were significantly lower in medulla than in the cortex for all of the participants. All of the IVIM parameters were significantly lower in the CKD patients than in the healthy controls. In the CKD patients, a significant negative correlation was found between the renal parenchymal D, D*,f values and the 24h-UPRO, as well as between the renal parenchymal D, f values and the SCr. There was a significant positive correlation between all of the IVIM parameters and the eGFR. All of the IVIM parameters exhibited a significant negative correlation with the histopathological fibrosis score. CONCLUSION: IVIM-DWI shows great potential in the noninvasive assessment of renal fibrosis in CKD.
PURPOSE: To investigate the potential of Intravoxel incoherent motion diffusion-weighted imaging(IVIM-DWI) for the assessment of renal fibrosis in chronic kidney disease (CKD), using histopathology as a reference standard. METHODS: Eighty-five CKDpatients and twenty healthy volunteers were recruited in this study. IVIM-DWI was performed in all of the participants, and all of the CKDpatients underwent renal biopsy. The mean values of the true diffusion coefficient (D), pseudo diffusion coefficient (D*) and perfusion fraction (f) in the renal cortex and medulla were compared between the CKDpatients and healthy volunteers. The Spearman correlation coefficient was calculated to assess the relationship between the D, D*,f values and the estimated glomerular filtration rate (eGFR), serum creatinine level (SCr), 24h urinary protein level (24h-UPRO), histopathological fibrosis scores. RESULTS: The D, D* and f values were significantly lower in medulla than in the cortex for all of the participants. All of the IVIM parameters were significantly lower in the CKDpatients than in the healthy controls. In the CKDpatients, a significant negative correlation was found between the renal parenchymal D, D*,f values and the 24h-UPRO, as well as between the renal parenchymal D, f values and the SCr. There was a significant positive correlation between all of the IVIM parameters and the eGFR. All of the IVIM parameters exhibited a significant negative correlation with the histopathological fibrosis score. CONCLUSION: IVIM-DWI shows great potential in the noninvasive assessment of renal fibrosis in CKD.
Authors: Anand Srivastava; Xuan Cai; Jungwha Lee; Wei Li; Brett Larive; Cynthia Kendrick; Jennifer J Gassman; John P Middleton; James Carr; Kalani L Raphael; Alfred K Cheung; Dominic S Raj; Michel B Chonchol; Linda F Fried; Geoffrey A Block; Stuart M Sprague; Myles Wolf; Joachim H Ix; Pottumarthi V Prasad; Tamara Isakova Journal: Clin J Am Soc Nephrol Date: 2020-04-28 Impact factor: 8.237
Authors: Pottumarthi V Prasad; Lu-Ping Li; Jon M Thacker; Wei Li; Bradley Hack; Orly Kohn; Stuart M Sprague Journal: Am J Nephrol Date: 2019-01-22 Impact factor: 3.754