INTRODUCTION: Ablation of persistent atrial fibrillation (AF) is a potential treatment option for symptomatic patients. We sought to evaluate the critical role of circumferential pulmonary vein isolation (CPVI) in the ablation of persistent AF. METHODS AND RESULTS: A total of 341 ablation procedures were performed in 174 consecutive patients with persistent AF. CPVI was performed in all patients, additional ablation was only performed if electrical cardioversion failed after CPVI. During a median follow-up (FU) of 89 (63; 89) months, stable sinus rhythm was documented in 42/170 (25%) patients after a single procedure and in 111/164 (68%) patients after 1.9 ± 1.1 procedures. Stable SR was achieved in 40/75 (53%) patients in whom only CPVI was performed during the index and repeat procedures and in 71/89 (79%) patients with CPVI plus additional ablation. The main predictor for ablation success was duration of persistent AF before the index procedure (P < 0.001, HR ± CI: 1.608 [1.034, 1.103]). Responders to CPVI during the initial procedure had a significantly better multiple-procedure outcome after 42 months of FU compared to CPVI nonresponders (P = 0.0365). Conversion during the index procedure had no impact on clinical outcomes (P = 0.0903). Persistent AF regressed to paroxysmal AF in 16% of patients. CONCLUSIONS: We demonstrate a 25% single- and 68% multiple-procedure success in patients with persistent AF, while stable SR was achieved in 53% of patients with pure CPVI during all procedures and in 79% of patients with CPVI plus additional ablation. Only duration of persistent AF before ablation had a statistically significant impact on ablation outcome.
INTRODUCTION: Ablation of persistent atrial fibrillation (AF) is a potential treatment option for symptomatic patients. We sought to evaluate the critical role of circumferential pulmonary vein isolation (CPVI) in the ablation of persistent AF. METHODS AND RESULTS: A total of 341 ablation procedures were performed in 174 consecutive patients with persistent AF. CPVI was performed in all patients, additional ablation was only performed if electrical cardioversion failed after CPVI. During a median follow-up (FU) of 89 (63; 89) months, stable sinus rhythm was documented in 42/170 (25%) patients after a single procedure and in 111/164 (68%) patients after 1.9 ± 1.1 procedures. Stable SR was achieved in 40/75 (53%) patients in whom only CPVI was performed during the index and repeat procedures and in 71/89 (79%) patients with CPVI plus additional ablation. The main predictor for ablation success was duration of persistent AF before the index procedure (P < 0.001, HR ± CI: 1.608 [1.034, 1.103]). Responders to CPVI during the initial procedure had a significantly better multiple-procedure outcome after 42 months of FU compared to CPVI nonresponders (P = 0.0365). Conversion during the index procedure had no impact on clinical outcomes (P = 0.0903). Persistent AF regressed to paroxysmal AF in 16% of patients. CONCLUSIONS: We demonstrate a 25% single- and 68% multiple-procedure success in patients with persistent AF, while stable SR was achieved in 53% of patients with pure CPVI during all procedures and in 79% of patients with CPVI plus additional ablation. Only duration of persistent AF before ablation had a statistically significant impact on ablation outcome.
Authors: Vincent Sayseng; Julien Grondin; Vasant A Salgaonkar; Christopher S Grubb; Maryam Basij; Mohammad Mehrmohammadi; Vivek Iyer; Daniel Wang; Hasan Garan; Elaine Y Wan; Elisa E Konofagou Journal: IEEE Trans Ultrason Ferroelectr Freq Control Date: 2020-04-15 Impact factor: 2.725
Authors: Marit Wiersma; Denise M S van Marion; Rob C I Wüst; Riekelt H Houtkooper; Deli Zhang; Natasja M S de Groot; Robert H Henning; Bianca J J M Brundel Journal: Cells Date: 2019-10-05 Impact factor: 6.600
Authors: Alena Yakimenka; Dina Labib; Steven Dykstra; Yoko Mikami; Alessandro Satriano; Jacqueline Flewitt; Patricia Feuchter; Sandra Rivest; Andrew G Howarth; Carmen P Lydell; F Russell Quinn; Stephen B Wilton; James A White Journal: Front Cardiovasc Med Date: 2022-07-28
Authors: Laura Rottner; Barbara Bellmann; Tina Lin; Bruno Reissmann; Tobias Tönnis; Ruben Schleberger; Moritz Nies; Christiane Jungen; Leon Dinshaw; Niklas Klatt; Jannis Dickow; Paula Münkler; Christian Meyer; Andreas Metzner; Andreas Rillig Journal: Cardiol Ther Date: 2020-01-02