| Literature DB >> 29214413 |
Kevin David Shield1, Claire Marant Micallef2, Catherine de Martel3, Isabelle Heard4,5, Francis Megraud6, Martyn Plummer3, Jérôme Vignat2, Freddie Bray2, Isabelle Soerjomataram2.
Abstract
To provide an assessment of the burden of cancer in France in 2015 attributable to infectious agents. A systematic literature review in French representative cancer cases series was undertaken of the prevalence of infectious agents with the major associated cancer types. PubMed was searched for original studies published up to September 2016; random-effects meta-analyses were performed. Cancer incidence data were obtained from the French Cancer Registries Network, thereby allowing the calculation of national incidence estimates. The number of new cancer cases attributable to infectious agents was calculated using population-attributable fractions according to published methods. Of the 352,000 new cancer cases in France in 2015, 14,336 (4.1% of all new cancer cases) were attributable to infectious agents. The largest contributors were human papillomavirus (HPV) and Helicobacter pylori, responsible for 6333 and 4406 new cancer cases (1.8 and 1.3% of all new cancer cases) respectively. Infectious agents caused a non-negligible number of new cancer cases in France in 2015. Most of these cancers were preventable. The expansion of vaccination (i.e., for hepatitis B virus and HPV) and screen-and-treat programs (for HPV and hepatitis C virus, and possibly for H. pylori) could greatly reduce this cancer burden.Entities:
Keywords: Attributable fraction; France; Incidence; Infection; Neoplasms; Prevalence
Mesh：
Year: 2017 PMID： 29214413 DOI： 10.1007/s10654-017-0334-z
Source DB: PubMed Journal: Eur J Epidemiol ISSN： 0393-2990 Impact factor: 8.082