Claudia Sellitto Porto1, Valeria Santoro Bahia2, Sonia Maria Dozzi Brucki2, Paulo Caramelli3, Ricardo Nitrini2. 1. PhD. Behavioral and Cognitive Neurology Unit, Department of Neurology of the University of São Paulo School of Medicine and Cognitive Disorders Reference Center (CEREDIC), Hospital das Clínicas of the University of São Paulo School of Medicine, São Paulo (SP), Brazil. 2. MD, PhD. Behavioral and Cognitive Neurology Unit, Department of Neurology of the University of São Paulo School of Medicine and Cognitive Disorders Reference Center (CEREDIC), Hospital das Clínicas of the University of São Paulo School of Medicine, São Paulo (SP), Brazil. 3. MD, PhD. Behavioral and Cognitive Neurology Unit, Department of Internal Medicine, Faculty of Medicine, Federal University of Minas Gerais, Belo Horizonte (MG), Brazil.
Abstract
Memory impairment is the main clinical feature in Alzheimer disease (AD), whereas in frontotemporal lobar degeneration (FTLD) behavioral and language disorders predominate. OBJECTIVES: To investigate possible differences between the neuropsychological performance in FTLD and AD. METHODS: Fifty-six AD patients (mean age=72.98±7.43; mean schooling=9.62±4.68; 35 women and 21 men), 17 FTLD patients (mean age=67.64±7.93; mean schooling=12.12±4.77; 9 women and 8 men), and 60 controls (mean age=68.90±7.48; mean schooling=10.72±4.74; 42 women and 18 men) were submitted to a Dementia Rating Scale (DRS) and a comprehensive neuropsychological evaluation composed of tasks assessing attention, visuoperceptual abilities, constructive abilities, executive functions, memory and language. RESULTS: DRS total score and subscales were not able to differentiate FTLD from AD patients. However, FTLD and AD patients showed statistically significant differences in performance in tests of verbal (Logical Memory, Rey Auditory Verbal Learning Test) and visual (Visual Reproduction, recall of the Rey Complex Figure) episodic memory, verbal immediate memory (Logical Memory), attention with interference (Trail Making Test - Part B), verbal fluency (semantic and phonemic) and concept formation (WCST). CONCLUSION: Contrary to expectations, only a few tasks executive function tasks (Trail Making Test - Part B, F.A.S. and WCST) and two memory tests (verbal and visual episodic memory tests) were able to differentiate between FTLD and AD patients.
Memory impairment is the main clinical feature in Alzheimer disease (AD), whereas in frontotemporal lobar degeneration (FTLD) behavioral and language disorders predominate. OBJECTIVES: To investigate possible differences between the neuropsychological performance in FTLD and AD. METHODS: Fifty-six AD patients (mean age=72.98±7.43; mean schooling=9.62±4.68; 35 women and 21 men), 17 FTLD patients (mean age=67.64±7.93; mean schooling=12.12±4.77; 9 women and 8 men), and 60 controls (mean age=68.90±7.48; mean schooling=10.72±4.74; 42 women and 18 men) were submitted to a Dementia Rating Scale (DRS) and a comprehensive neuropsychological evaluation composed of tasks assessing attention, visuoperceptual abilities, constructive abilities, executive functions, memory and language. RESULTS: DRS total score and subscales were not able to differentiate FTLD from AD patients. However, FTLD and AD patients showed statistically significant differences in performance in tests of verbal (Logical Memory, Rey Auditory Verbal Learning Test) and visual (Visual Reproduction, recall of the Rey Complex Figure) episodic memory, verbal immediate memory (Logical Memory), attention with interference (Trail Making Test - Part B), verbal fluency (semantic and phonemic) and concept formation (WCST). CONCLUSION: Contrary to expectations, only a few tasks executive function tasks (Trail Making Test - Part B, F.A.S. and WCST) and two memory tests (verbal and visual episodic memory tests) were able to differentiate between FTLD and AD patients.
Authors: Sonia E Zevallos Bustamante; Cássio M C Bottino; Marcos A Lopes; Dionísio Azevedo; Sérgio R Hototian; Júlio Litvoc; Wilson Jacob Filho Journal: Arq Neuropsiquiatr Date: 2003-09-16 Impact factor: 1.420
Authors: B Alescio-Lautier; B F Michel; C Herrera; A Elahmadi; C Chambon; C Touzet; V Paban Journal: Neuropsychologia Date: 2007-02-01 Impact factor: 3.139
Authors: Fernando Henríquez; Victoria Cabello; Sandra Baez; Leonardo Cruz de Souza; Patricia Lillo; David Martínez-Pernía; Loreto Olavarría; Teresa Torralva; Andrea Slachevsky Journal: Front Neurol Date: 2022-02-16 Impact factor: 4.003