Avril Mason1, Konstantinos Gerasimidis2, Jelena Iljuhhina2, Susan Laird3, Joanne Munro3, Daniel R Gaya3, Richard K Russell4, S Faisal Ahmed1. 1. Developmental Endocrinology Research Group, School of Medicine, College of Medical, Veterinary and Life Sciences, University of Glasgow, Royal Hospital for Children, Glasgow, United Kingdom. 2. Human Nutrition, School of Medicine, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow Royal Infirmary, Glasgow, United Kingdom. 3. Department of Gastroenterology, Glasgow Royal Infirmary, Glasgow, United Kingdom. 4. Department of Paediatric Gastroenterology, Hepatology and Nutrition, Royal Hospital for Children, Glasgow, United Kingdom.
Abstract
BACKGROUND: It is unclear whether Crohn's disease (CD) is associated with skeletal disproportion in adulthood. METHODS: Height (Ht), sitting height (SHt) and leg length were studied in 44 children (male: 22), 23 adults (male: 10) with childhood-onset (CO) CD and 26 adults (male: 9) with adult-onset (AO) CD with a median (range) age of 13.7 (10, 17.3), 21.5 (18, 32) and 31.0 (22, 40) years, respectively. RESULTS: Adults with CO-CD had a median Ht standard deviation score (SDS) of -0.9 (-2.3, 0.0) compared to 0.6 (-0.8, 1.0) in those with AO-CD (p < 0.05). Compared to a normal population, men, but not women, with CO-CD also had lower median SHt SDS at -1.1 (2.5, -0.5) (p < 0.05). The expected positive association that is normally found between leg length and SHt SDS was not evident in the adults with CO-CD. CONCLUSION: Short stature in adults with CO-CD is more pronounced in men and may be associated with poor spinal growth.
BACKGROUND: It is unclear whether Crohn's disease (CD) is associated with skeletal disproportion in adulthood. METHODS: Height (Ht), sitting height (SHt) and leg length were studied in 44 children (male: 22), 23 adults (male: 10) with childhood-onset (CO) CD and 26 adults (male: 9) with adult-onset (AO) CD with a median (range) age of 13.7 (10, 17.3), 21.5 (18, 32) and 31.0 (22, 40) years, respectively. RESULTS: Adults with CO-CD had a median Ht standard deviation score (SDS) of -0.9 (-2.3, 0.0) compared to 0.6 (-0.8, 1.0) in those with AO-CD (p < 0.05). Compared to a normal population, men, but not women, with CO-CD also had lower median SHt SDS at -1.1 (2.5, -0.5) (p < 0.05). The expected positive association that is normally found between leg length and SHt SDS was not evident in the adults with CO-CD. CONCLUSION: Short stature in adults with CO-CD is more pronounced in men and may be associated with poor spinal growth.
Authors: Neera Gupta; Robert H Lustig; Howard Andrews; Francisco Sylvester; David Keljo; Alka Goyal; Ranjana Gokhale; Ashish S Patel; Stephen Guthery; Cheng-Shiun Leu Journal: Inflamm Bowel Dis Date: 2020-11-19 Impact factor: 5.325
Authors: Neera Gupta; Robert H Lustig; Howard Andrews; Ranjana Gokhale; Alka Goyal; Ashish S Patel; Stephen Guthery; Francisco Sylvester; Leah Siebold; Cheng-Shiun Leu Journal: Inflamm Bowel Dis Date: 2021-05-17 Impact factor: 7.290