Neera Gupta1, Robert H Lustig2, Howard Andrews3, Francisco Sylvester4, David Keljo5, Alka Goyal6, Ranjana Gokhale7, Ashish S Patel8, Stephen Guthery9, Cheng-Shiun Leu10. 1. Department of Pediatrics, Weill Cornell Medicine, New York, NY. 2. Division of Endocrinology, Department of Pediatrics, University of California, San Francisco, San Francisco, CA. 3. Department of Biostatistics, Mailman School of Public Health, Columbia University, New York City, NY. 4. Division of Pediatric Gastroenterology, University of North Carolina at Chapel Hill, Chapel Hill, NC. 5. Division of Gastroenterology, Hepatology and Nutrition, Children's Hospital of Pittsburgh of UPMC, Pittsburgh, PA. 6. Division of Gastroenterology, Hepatology and Nutrition, Children's Mercy Kansas City, Kansas City, MI. 7. Section of Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, University of Chicago Comer Children's Hospital, Chicago, IL. 8. Division of Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, UT Southwestern Medical Center, Dallas, TX. 9. Division of Gastroenterology, Hepatology, and Nutrition, Primary Children's Hospital and the University of Utah, Salt Lake City, UT. 10. Department of Biostatistics, Columbia University Medical Center, New York City, NY.
Abstract
BACKGROUND: Statural growth impairment is more common in males with Crohn's disease (CD). We assessed sex differences in height Z score differences and bone age (BA) Z scores and characterized age of menarche in a novel contemporary cohort of pediatric CD patients undergoing screening for enrollment in the multicenter longitudinal Growth Study. METHODS: Crohn's disease patients (females with chronological age [CA] 5 years and older and younger than 14 years; males with CA 6 years and older and younger than 16 years) participated in a screening visit for the Growth Study. Height BA-Z scores are height Z scores calculated based on BA. Height CA-Z scores are height Z scores calculated based on CA. The height Z score difference equals height CA-Z score minus height BA-Z score. RESULTS: One hundred seventy-one patients (60% male) qualified for this analysis. Mean CA was 12.2 years. Mean height CA-Z score was -0.4, and mean height BA-Z score was 0.4 in females. Mean height CA-Z score was -0.1, and mean height BA-Z score was 0.2 in males. The absolute value of the mean height Z score difference was significantly greater in females (0.8) than males (0.3; P = 0.005). The mean BA-Z score in females (-1.0) was significantly lower than in males (-0.2; P = 0.002). The median CA at menarche was 13.6 (95% CI, 12.6-14.6) years. CONCLUSIONS: Our screening visit data suggest that standardized height gain is lower in males with skeletal maturation and delayed puberty is common in females in CD. We are investigating these findings in the ongoing Growth Study.
BACKGROUND:Statural growth impairment is more common in males with Crohn's disease (CD). We assessed sex differences in height Z score differences and bone age (BA) Z scores and characterized age of menarche in a novel contemporary cohort of pediatric CDpatients undergoing screening for enrollment in the multicenter longitudinal Growth Study. METHODS:Crohn's diseasepatients (females with chronological age [CA] 5 years and older and younger than 14 years; males with CA 6 years and older and younger than 16 years) participated in a screening visit for the Growth Study. Height BA-Z scores are height Z scores calculated based on BA. Height CA-Z scores are height Z scores calculated based on CA. The height Z score difference equals height CA-Z score minus height BA-Z score. RESULTS: One hundred seventy-one patients (60% male) qualified for this analysis. Mean CA was 12.2 years. Mean height CA-Z score was -0.4, and mean height BA-Z score was 0.4 in females. Mean height CA-Z score was -0.1, and mean height BA-Z score was 0.2 in males. The absolute value of the mean height Z score difference was significantly greater in females (0.8) than males (0.3; P = 0.005). The mean BA-Z score in females (-1.0) was significantly lower than in males (-0.2; P = 0.002). The median CA at menarche was 13.6 (95% CI, 12.6-14.6) years. CONCLUSIONS: Our screening visit data suggest that standardized height gain is lower in males with skeletal maturation and delayed puberty is common in females in CD. We are investigating these findings in the ongoing Growth Study.
Authors: Neera Gupta; Robert H Lustig; Michael A Kohn; Marjorie McCracken; Eric Vittinghoff Journal: Inflamm Bowel Dis Date: 2011-02-01 Impact factor: 5.325
Authors: Rebecca J Hill; Denise S K Brookes; Peter J Lewindon; Geoffrey D Withers; Looi C Ee; Frances L Connor; Geoffrey J Cleghorn; Peter S W Davies Journal: J Pediatr Gastroenterol Nutr Date: 2009-05 Impact factor: 2.839
Authors: Marian Pfefferkorn; Georgine Burke; Anne Griffiths; James Markowitz; Joel Rosh; David Mack; Anthony Otley; Subra Kugathasan; Jonathan Evans; Athos Bousvaros; M Susan Moyer; Robert Wyllie; Maria Oliva-Hemker; Ryan Carvalho; Wallace Crandall; David Keljo; T D Walters; Neal LeLeiko; Jeffrey Hyams Journal: J Pediatr Gastroenterol Nutr Date: 2009-02 Impact factor: 2.839
Authors: Neera Gupta; Alan G Bostrom; Barbara S Kirschner; George D Ferry; Harland S Winter; Robert N Baldassano; Benjamin D Gold; Oren Abramson; Terry Smith; Stanley A Cohen; Melvin B Heyman Journal: Pediatrics Date: 2007-12 Impact factor: 7.124
Authors: Neera Gupta; Robert H Lustig; Howard Andrews; Ranjana Gokhale; Alka Goyal; Ashish S Patel; Stephen Guthery; Francisco Sylvester; Leah Siebold; Cheng-Shiun Leu Journal: Inflamm Bowel Dis Date: 2021-05-17 Impact factor: 7.290