Literature DB >> 29211977

Waste Not, Want Not: Lactate Oxidation Fuels the TCA Cycle.

Inmaculada Martínez-Reyes1, Navdeep S Chandel2.   

Abstract

Previous studies have demonstrated that mitochondrial respiration is essential for tumorigenesis. Hui et al. (2017) and Faubert et al. (2017) demonstrate that lactate, traditionally viewed as a waste product of anaerobic and aerobic glycolysis, is a major carbon source to fuel the mitochondrial TCA cycle in normal tissue and in tumors.
Copyright © 2017 Elsevier Inc. All rights reserved.

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Year:  2017        PMID： 29211977     DOI： 10.1016/j.cmet.2017.11.005

Source DB:  PubMed          Journal:  Cell Metab        ISSN： 1550-4131            Impact factor:   27.287


  11 in total

1.  INCA 2.0: A tool for integrated, dynamic modeling of NMR- and MS-based isotopomer measurements and rigorous metabolic flux analysis.

Authors:  Mohsin Rahim; Mukundan Ragavan; Stanislaw Deja; Matthew E Merritt; Shawn C Burgess; Jamey D Young
Journal:  Metab Eng       Date:  2021-12-26       Impact factor: 9.783

Review 2.  In vivo2H/13C flux analysis in metabolism research.

Authors:  Tomasz K Bednarski; Mohsin Rahim; Jamey D Young
Journal:  Curr Opin Biotechnol       Date:  2021-05-25       Impact factor: 10.279

3.  Metabolomic profiling of anaerobic and aerobic energy metabolic pathways in chronic obstructive pulmonary disease.

Authors:  Mingshan Xue; Yifeng Zeng; Runpei Lin; Hui-Qi Qu; Teng Zhang; Xiaohua Douglas Zhang; Yueting Liang; Yingjie Zhen; Hao Chen; Zhifeng Huang; Haisheng Hu; Peiyan Zheng; Hakon Hakonarson; Luqian Zhou; Baoqing Sun
Journal:  Exp Biol Med (Maywood)       Date:  2021-05-06

4.  A metabolic vulnerability of small-cell lung cancer.

Authors:  Miyuki Nomura; Mami Morita; Nobuhiro Tanuma
Journal:  Oncotarget       Date:  2018-08-17

5.  Functional changes of the liver in the absence of growth hormone (GH) action - Proteomic and metabolomic insights from a GH receptor deficient pig model.

Authors:  Evamaria O Riedel; Arne Hinrichs; Elisabeth Kemter; Maik Dahlhoff; Mattias Backman; Birgit Rathkolb; Cornelia Prehn; Jerzy Adamski; Simone Renner; Andreas Blutke; Martin Hrabĕ de Angelis; Martin Bidlingmaier; Jochen Schopohl; Georg J Arnold; Thomas Fröhlich; Eckhard Wolf
Journal:  Mol Metab       Date:  2020-03-18       Impact factor: 7.422

6.  Mitochondria as a Platform for Dictating the Cell Fate of Cultured Human Corneal Endothelial Cells.

Authors:  Kohsaku Numa; Morio Ueno; Tomoko Fujita; Koji Ueda; Nao Hiramoto; Atushi Mukai; Yuichi Tokuda; Masakazu Nakano; Chie Sotozono; Shigeru Kinoshita; Junji Hamuro
Journal:  Invest Ophthalmol Vis Sci       Date:  2020-12-01       Impact factor: 4.799

7.  Metabolites Interrogation in Cell Fate Decision of Cultured Human Corneal Endothelial Cells.

Authors:  Junji Hamuro; Kohsaku Numa; Tomoko Fujita; Munetoyo Toda; Koji Ueda; Yuichi Tokuda; Atushi Mukai; Masakazu Nakano; Morio Ueno; Shigeru Kinoshita; Chie Sotozono
Journal:  Invest Ophthalmol Vis Sci       Date:  2020-02-07       Impact factor: 4.799

8.  ITGB2-mediated metabolic switch in CAFs promotes OSCC proliferation by oxidation of NADH in mitochondrial oxidative phosphorylation system.

Authors:  Xiaoxin Zhang; Yingchun Dong; Mengxiang Zhao; Liang Ding; Xihu Yang; Yue Jing; Yuxian Song; Sheng Chen; Qingang Hu; Yanhong Ni
Journal:  Theranostics       Date:  2020-10-26       Impact factor: 11.556

9.  Value of Pyruvate Carboxylase in Thyroid Fine-Needle Aspiration Wash-Out Fluid for Predicting Papillary Thyroid Cancer Lymph Node Metastasis.

Authors:  Chang Liu; Lu Zhang; Yang Liu; Qingqing Zhao; Yu Pan; Yifan Zhang
Journal:  Front Oncol       Date:  2021-05-17       Impact factor: 6.244

10.  Advanced Cancer Starvation Therapy by Simultaneous Deprivation of Lactate and Glucose Using a MOF Nanoplatform.

Authors:  Jiantao Yu; Zixiang Wei; Qing Li; Feiyan Wan; Zhicong Chao; Xindan Zhang; Li Lin; Hong Meng; Leilei Tian
Journal:  Adv Sci (Weinh)       Date:  2021-08-07       Impact factor: 16.806
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