Literature DB >> 29209796

[Spindle-cell osteosclerotic bone lesion with MDM2 amplification].

C Mogler1, M Boxberg2, C Knebel3, W Weichert2, K Wörtler4, K Specht2.   

Abstract

This case report presents an osteosclerotic bone lesion in a 49-year-old man with MDM2 amplification. The final diagnosis shows metastasis to the bones from stomach cancer. In primary bone tumours, the MDM2 amplifications observed have been described for many other tumour entities as well, and therefore do not exclude bone metastasis from a carcinoma.

Entities:  

Keywords:  Bone neoplasms; Carcinoma; Gene amplification; Stomach neoplasm; Tumor biomarker

Mesh：

Substances：

Year:  2018        PMID： 29209796     DOI： 10.1007/s00292-017-0394-6

Source DB:  PubMed          Journal:  Pathologe        ISSN： 0172-8113            Impact factor:   1.011


  13 in total

1.  Frequency of Mouse Double Minute 2 (MDM2) and Mouse Double Minute 4 (MDM4) amplification in parosteal and conventional osteosarcoma subtypes.

Authors:  Laure A E Duhamel; Hongtao Ye; Dina Halai; Bernadine D Idowu; Nadège Presneau; Roberto Tirabosco; Adrienne M Flanagan
Journal:  Histopathology       Date:  2011-11-10       Impact factor: 5.087

2.  Mdm2 gene amplification in gastric cancer correlation with expression of Mdm2 protein and p53 alterations.

Authors:  T Günther; R Schneider-Stock; C Häckel; H U Kasper; M Pross; A Hackelsberger; H Lippert; A Roessner
Journal:  Mod Pathol       Date:  2000-06       Impact factor: 7.842

3.  Diagnosis and treatment of low-grade osteosarcoma: experience with nine cases.

Authors:  Katsuhiro Hayashi; Hiroyuki Tsuchiya; Norio Yamamoto; Toshiharu Shirai; Hideji Nishida; Akihiko Takeuchi; Hiroaki Kimura; Shinji Miwa; Hiroyuki Inatani; Hideki Okamoto; Satoshi Yamada; Hiroko Ikeda; Seiko Sawada-Kitamura; Takayuki Nojima; Akishi Ooi; Takanobu Otsuka
Journal:  Int J Clin Oncol       Date:  2013-07-24       Impact factor: 3.402

Review 4.  Parosteal osteosarcoma.

Authors:  Jen-Fan Hang; Paul Chih-Hsueh Chen
Journal:  Arch Pathol Lab Med       Date:  2014-05       Impact factor: 5.534

5.  MDM2 gene amplification and protein expressions in colon carcinoma: is targeting MDM2 a new therapeutic option?

Authors:  Monirath Hav; Louis Libbrecht; Liesbeth Ferdinande; Piet Pattyn; Stephanie Laurent; Marc Peeters; Marleen Praet; Patrick Pauwels
Journal:  Virchows Arch       Date:  2010-11-27       Impact factor: 4.064

Review 6.  Clinical and molecular approaches to well differentiated and dedifferentiated liposarcoma.

Authors:  Aimee M Crago; Samuel Singer
Journal:  Curr Opin Oncol       Date:  2011-07       Impact factor: 3.645

Review 7.  Genetic instability in osteoblastic tumors of the skeletal system.

Authors:  K Radig; R Schneider-Stock; U Mittler; H W Neumann; A Roessner
Journal:  Pathol Res Pract       Date:  1998       Impact factor: 3.250

8.  Characterization of 298 Patients with Lung Cancer Harboring MET Exon 14 Skipping Alterations.

Authors:  Alexa B Schrock; Garrett M Frampton; James Suh; Zachary R Chalmers; Mark Rosenzweig; Rachel L Erlich; Balazs Halmos; Jonathan Goldman; Patrick Forde; Kurt Leuenberger; Nir Peled; Gregory P Kalemkerian; Jeffrey S Ross; Philip J Stephens; Vincent A Miller; Siraj M Ali; Sai-Hong Ignatius Ou
Journal:  J Thorac Oncol       Date:  2016-06-22       Impact factor: 15.609

Review 9.  Gastric cancer pathology and underlying molecular mechanisms.

Authors:  Heike I Grabsch; Patrick Tan
Journal:  Dig Surg       Date:  2013-07-18       Impact factor: 2.588

10.  p53 expression and relationship with MDM2 amplification in breast carcinomas.

Authors:  Nur Buyukpinarbasili; Zuhal Gucin; Yeliz Emine Ersoy; Ayca İlbak; Huseyin Kadioglu; Mahmut Muslumanoglu
Journal:  Ann Diagn Pathol       Date:  2016-01-08       Impact factor: 2.090
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