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Literature DB >> 29209653

Unveiling the role of VPS34 kinase domain dynamics in regulation of the autophagic PI3K complex.

Goran Stjepanovic^1,2, Sulochanadevi Baskaran¹, Mary G Lin¹, James H Hurley^1,2.

Abstract

The class III PI 3-kinase, VPS34 forms distinct complexes essential for cargo sorting and membrane trafficking in endocytosis as well as for autophagosome nucleation and maturation. We used integrative structural biology approach to provide insights into the conformational dynamics of the complex and mechanisms that regulate VPS34 activity at the membrane.

Entities: Gene

Keywords: Autophagy; VPS34; autophagy activators; lipid kinase; protein dynamics

Year: 2017 PMID： 29209653 PMCID： PMC5706946 DOI： 10.1080/23723556.2017.1367873

Source DB: PubMed Journal: Mol Cell Oncol ISSN： 2372-3556

10 in total

Review 1. Pharmacological modulation of autophagy: therapeutic potential and persisting obstacles.

Authors: Lorenzo Galluzzi; José Manuel Bravo-San Pedro; Beth Levine; Douglas R Green; Guido Kroemer
Journal: Nat Rev Drug Discov Date: 2017-05-19 Impact factor: 84.694

2. Vps34 Kinase Domain Dynamics Regulate the Autophagic PI 3-Kinase Complex.

Authors: Goran Stjepanovic; Sulochanadevi Baskaran; Mary G Lin; James H Hurley
Journal: Mol Cell Date: 2017-07-27 Impact factor: 17.970

Review 3. The intricate regulation and complex functions of the Class III phosphoinositide 3-kinase Vps34.

Authors: Jonathan M Backer
Journal: Biochem J Date: 2016-08-01 Impact factor: 3.857

Review 4. Autophagy in malignant transformation and cancer progression.

Authors: Lorenzo Galluzzi; Federico Pietrocola; José Manuel Bravo-San Pedro; Ravi K Amaravadi; Eric H Baehrecke; Francesco Cecconi; Patrice Codogno; Jayanta Debnath; David A Gewirtz; Vassiliki Karantza; Alec Kimmelman; Sharad Kumar; Beth Levine; Maria Chiara Maiuri; Seamus J Martin; Josef Penninger; Mauro Piacentini; David C Rubinsztein; Hans-Uwe Simon; Anne Simonsen; Andrew M Thorburn; Guillermo Velasco; Kevin M Ryan; Guido Kroemer
Journal: EMBO J Date: 2015-02-23 Impact factor: 11.598

5. Induction of autophagy and inhibition of tumorigenesis by beclin 1.

Authors: X H Liang; S Jackson; M Seaman; K Brown; B Kempkes; H Hibshoosh; B Levine
Journal: Nature Date: 1999-12-09 Impact factor: 49.962

Review 6. Mechanisms of Autophagy Initiation.

Authors: James H Hurley; Lindsey N Young
Journal: Annu Rev Biochem Date: 2017-03-15 Impact factor: 23.643

7. Two distinct Vps34 phosphatidylinositol 3-kinase complexes function in autophagy and carboxypeptidase Y sorting in Saccharomyces cerevisiae.

Authors: A Kihara; T Noda; N Ishihara; Y Ohsumi
Journal: J Cell Biol Date: 2001-02-05 Impact factor: 10.539

8. Structure and flexibility of the endosomal Vps34 complex reveals the basis of its function on membranes.

Authors: Ksenia Rostislavleva; Nicolas Soler; Yohei Ohashi; Lufei Zhang; Els Pardon; John E Burke; Glenn R Masson; Chris Johnson; Jan Steyaert; Nicholas T Ktistakis; Roger L Williams
Journal: Science Date: 2015-10-09 Impact factor: 47.728

9. FIP200, a ULK-interacting protein, is required for autophagosome formation in mammalian cells.

Authors: Taichi Hara; Akito Takamura; Chieko Kishi; Shun-Ichiro Iemura; Tohru Natsume; Jun-Lin Guan; Noboru Mizushima
Journal: J Cell Biol Date: 2008-04-28 Impact factor: 10.539

10. Architecture and dynamics of the autophagic phosphatidylinositol 3-kinase complex.

Authors: Sulochanadevi Baskaran; Lars-Anders Carlson; Goran Stjepanovic; Lindsey N Young; Do Jin Kim; Patricia Grob; Robin E Stanley; Eva Nogales; James H Hurley
Journal: Elife Date: 2014-12-09 Impact factor: 8.140

10 in total

5 in total

Unveiling the role of VPS34 kinase domain dynamics in regulation of the autophagic PI3K complex.

Review 1. Pharmacological modulation of autophagy: therapeutic potential and persisting obstacles.

2. Vps34 Kinase Domain Dynamics Regulate the Autophagic PI 3-Kinase Complex.

Review 3. The intricate regulation and complex functions of the Class III phosphoinositide 3-kinase Vps34.

Review 4. Autophagy in malignant transformation and cancer progression.

5. Induction of autophagy and inhibition of tumorigenesis by beclin 1.

Review 6. Mechanisms of Autophagy Initiation.

7. Two distinct Vps34 phosphatidylinositol 3-kinase complexes function in autophagy and carboxypeptidase Y sorting in Saccharomyces cerevisiae.

8. Structure and flexibility of the endosomal Vps34 complex reveals the basis of its function on membranes.

9. FIP200, a ULK-interacting protein, is required for autophagosome formation in mammalian cells.

10. Architecture and dynamics of the autophagic phosphatidylinositol 3-kinase complex.

1. Class III PI3K Biology.

Review 2. Redox homeostasis, oxidative stress and mitophagy.

3. Initial Steps in Mammalian Autophagosome Biogenesis.

Review 4. AMPK: Regulation of Metabolic Dynamics in the Context of Autophagy.

Review 5. VPS34 complexes from a structural perspective.