Literature DB >> 29209650

KEAP1 has a sweet spot: A new connection between intracellular glycosylation and redox stress signaling in cancer cells.

Po-Han Chen1,2, Jen-Tsan Chi2, Michael Boyce1.   

Abstract

The KEAP1/NRF2 pathway is a master regulator of the redox stress response and is dysregulated in numerous human tumors. We discovered that NRF2 signaling is controlled by the site-specific glycosylation of KEAP1, revealing a potentially broad link among nutrient sensing, proteostasis and stress resistance in both normal and cancer cells.

Entities:  

Year:  2017        PMID： 29209650      PMCID： PMC5706953          DOI： 10.1080/23723556.2017.1361501

Source DB:  PubMed          Journal:  Mol Cell Oncol        ISSN： 2372-3556


  10 in total

Review 1.  From Krebs to clinic: glutamine metabolism to cancer therapy.

Authors:  Brian J Altman; Zachary E Stine; Chi V Dang
Journal:  Nat Rev Cancer       Date:  2016-07-29       Impact factor: 60.716

2.  A Cullin3-KLHL20 Ubiquitin ligase-dependent pathway targets PML to potentiate HIF-1 signaling and prostate cancer progression.

Authors:  Wei-Chien Yuan; Yu-Ru Lee; Shiu-Feng Huang; Yu-Min Lin; Tzu-Yin Chen; Hsiang-Ching Chung; Chin-Hsien Tsai; Hsin-Yi Chen; Cheng-Ta Chiang; Chun-Kai Lai; Li-Ting Lu; Chun-Hau Chen; De-Leung Gu; Yeong-Shiau Pu; Yuh-Shan Jou; Kun Ping Lu; Pei-Wen Hsiao; Hsiu-Ming Shih; Ruey-Hwa Chen
Journal:  Cancer Cell       Date:  2011-08-16       Impact factor: 31.743

Review 3.  Cross talk between O-GlcNAcylation and phosphorylation: roles in signaling, transcription, and chronic disease.

Authors:  Gerald W Hart; Chad Slawson; Genaro Ramirez-Correa; Olof Lagerlof
Journal:  Annu Rev Biochem       Date:  2011       Impact factor: 23.643

Review 4.  O-GlcNAcylation in Cancer Biology: Linking Metabolism and Signaling.

Authors:  Christina M Ferrer; Valerie L Sodi; Mauricio J Reginato
Journal:  J Mol Biol       Date:  2016-06-23       Impact factor: 5.469

Review 5.  The Emerging Hallmarks of Cancer Metabolism.

Authors:  Natalya N Pavlova; Craig B Thompson
Journal:  Cell Metab       Date:  2016-01-12       Impact factor: 27.287

Review 6.  The Dual Roles of NRF2 in Cancer.

Authors:  Silvia Menegon; Amedeo Columbano; Silvia Giordano
Journal:  Trends Mol Med       Date:  2016-06-02       Impact factor: 11.951

7.  Glycosylation of KEAP1 links nutrient sensing to redox stress signaling.

Authors:  Po-Han Chen; Timothy J Smith; Jianli Wu; Priscila F Siesser; Brittany J Bisnett; Farhan Khan; Maxwell Hogue; Erik Soderblom; Flora Tang; Jeffrey R Marks; Michael B Major; Benjamin M Swarts; Michael Boyce; Jen-Tsan Chi
Journal:  EMBO J       Date:  2017-06-29       Impact factor: 11.598

Review 8.  The emerging role of the Nrf2-Keap1 signaling pathway in cancer.

Authors:  Melba C Jaramillo; Donna D Zhang
Journal:  Genes Dev       Date:  2013-10-15       Impact factor: 11.361

Review 9.  A little sugar goes a long way: the cell biology of O-GlcNAc.

Authors:  Michelle R Bond; John A Hanover
Journal:  J Cell Biol       Date:  2015-03-30       Impact factor: 10.539

10.  Update on the Kelch-like (KLHL) gene family.

Authors:  Bajinder S Dhanoa; Tiziana Cogliati; Akhila G Satish; Elspeth A Bruford; James S Friedman
Journal:  Hum Genomics       Date:  2013-05-15       Impact factor: 4.639
  10 in total
  4 in total

Review 1.  Functional crosstalk among oxidative stress and O-GlcNAc signaling pathways.

Authors:  Po-Han Chen; Jen-Tsan Chi; Michael Boyce
Journal:  Glycobiology       Date:  2018-08-01       Impact factor: 4.313

2.  DDR2 upregulation confers ferroptosis susceptibility of recurrent breast tumors through the Hippo pathway.

Authors:  Chao-Chieh Lin; Wen-Hsuan Yang; Yi-Tzu Lin; Xiaohu Tang; Po-Han Chen; Chien-Kuang Cornelia Ding; Dan Chen Qu; James V Alvarez; Jen-Tsan Chi
Journal:  Oncogene       Date:  2021-02-18       Impact factor: 9.867

3.  Gigaxonin glycosylation regulates intermediate filament turnover and may impact giant axonal neuropathy etiology or treatment

Authors:  Po-Han Chen; Jimin Hu; Jianli Wu; Duc T Huynh; Timothy J Smith; Samuel Pan; Brittany J Bisnett; Alexander B Smith; Annie Lu; Brett M Condon; Jen-Tsan Chi; Michael Boyce
Journal:  JCI Insight       Date:  2019-11-26

4.  Zinc transporter ZIP7 is a novel determinant of ferroptosis.

Authors:  Po-Han Chen; Jianli Wu; Yitong Xu; Chien-Kuang Cornelia Ding; Alexander A Mestre; Chao-Chieh Lin; Wen-Hsuan Yang; Jen-Tsan Chi
Journal:  Cell Death Dis       Date:  2021-02-19       Impact factor: 8.469
  4 in total

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