Literature DB >> 29209644

New role of endoplasmic reticulum chaperones in regulating metaplasia during tumorigenesis.

Jieli Shen1, Daisy F Rangel1, Dat Ha1, Amy S Lee1.   

Abstract

Metaplasia is emerging as a key process in tumorigenesis. We discovered that 2 essential endoplasmic reticulum (ER) chaperones, 78-kilodalton glucose-regulated protein (GRP78) and 94-kilodalton glucose-regulated protein (GRP94) have a role in metaplasia. Grp78 haploinsufficiency in the mouse pancreas impairs acinar-to-ductal metaplasia, whereas in the uterus, Grp94 loss induces squamous cell metaplasia; both resulting in tumor suppression.

Entities:  

Keywords:  ER chaperone; GRP78; GRP94; metaplasia; mouse models; pancreatic cancer

Year:  2017        PMID： 29209644      PMCID： PMC5706948          DOI： 10.1080/23723556.2017.1345350

Source DB:  PubMed          Journal:  Mol Cell Oncol        ISSN： 2372-3556


  10 in total

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Authors:  David Tosh; Jonathan M W Slack
Journal:  Nat Rev Mol Cell Biol       Date:  2002-03       Impact factor: 94.444

Review 2.  Glucose-regulated proteins in cancer: molecular mechanisms and therapeutic potential.

Authors:  Amy S Lee
Journal:  Nat Rev Cancer       Date:  2014-04       Impact factor: 60.716

3.  EGF receptor is required for KRAS-induced pancreatic tumorigenesis.

Authors:  Christine M Ardito; Barbara M Grüner; Kenneth K Takeuchi; Clara Lubeseder-Martellato; Nicole Teichmann; Pawel K Mazur; Kathleen E Delgiorno; Eileen S Carpenter; Christopher J Halbrook; Jason C Hall; Debjani Pal; Thomas Briel; Alexander Herner; Marija Trajkovic-Arsic; Bence Sipos; Geou-Yarh Liou; Peter Storz; Nicole R Murray; David W Threadgill; Maria Sibilia; M Kay Washington; Carole L Wilson; Roland M Schmid; Elaine W Raines; Howard C Crawford; Jens T Siveke
Journal:  Cancer Cell       Date:  2012-09-11       Impact factor: 31.743

4.  GRP78 haploinsufficiency suppresses acinar-to-ductal metaplasia, signaling, and mutant Kras-driven pancreatic tumorigenesis in mice.

Authors:  Jieli Shen; Dat P Ha; Genyuan Zhu; Daisy F Rangel; Agnieszka Kobielak; Parkash S Gill; Susan Groshen; Louis Dubeau; Amy S Lee
Journal:  Proc Natl Acad Sci U S A       Date:  2017-05-01       Impact factor: 11.205

Review 5.  ER chaperones in mammalian development and human diseases.

Authors:  Min Ni; Amy S Lee
Journal:  FEBS Lett       Date:  2007-04-25       Impact factor: 4.124

6.  Identification of Sox9-dependent acinar-to-ductal reprogramming as the principal mechanism for initiation of pancreatic ductal adenocarcinoma.

Authors:  Janel L Kopp; Guido von Figura; Erin Mayes; Fen-Fen Liu; Claire L Dubois; John P Morris; Fong Cheng Pan; Haruhiko Akiyama; Christopher V E Wright; Kristin Jensen; Matthias Hebrok; Maike Sander
Journal:  Cancer Cell       Date:  2012-11-29       Impact factor: 31.743

7.  Induced endoplasmic reticulum (ER) stress and binding of over-expressed ER specific chaperone GRP78/BiP with dimerized epidermal growth factor receptor in mammalian cells exposed to low concentration of N-methyl-N'-nitro-N-nitrosoguanidine.

Authors:  Geng Liu; Yi Shang; Yingnian Yu
Journal:  Mutat Res       Date:  2006-02-20       Impact factor: 2.433

8.  Targeting the glucose-regulated protein-78 abrogates Pten-null driven AKT activation and endometrioid tumorigenesis.

Authors:  Y G Lin; J Shen; E Yoo; R Liu; H-Y Yen; A Mehta; A Rajaei; W Yang; P Mhawech-Fauceglia; F J DeMayo; J Lydon; P Gill; A S Lee
Journal:  Oncogene       Date:  2015-02-16       Impact factor: 9.867

9.  Glucose-regulated protein 94 deficiency induces squamous cell metaplasia and suppresses PTEN-null driven endometrial epithelial tumor development.

Authors:  Jieli Shen; Lijing Yao; Yvonne G Lin; Francesco J DeMayo; John P Lydon; Louis Dubeau; Amy S Lee
Journal:  Oncotarget       Date:  2016-03-22

10.  The role of c-Src in the invasion and metastasis of hepatocellular carcinoma cells induced by association of cell surface GRP78 with activated α2M.

Authors:  Song Zhao; Hongdan Li; Qingjun Wang; Chang Su; Guan Wang; Huijuan Song; Liang Zhao; Zhidong Luan; Rongjian Su
Journal:  BMC Cancer       Date:  2015-05-10       Impact factor: 4.430
  10 in total

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